Epilepsy in patients with spina bifida in the lumbosacral region

Fumiaki Yoshida, Takato Morioka, Kimiaki Hashiguchi, Tadao Kawamura, Yasushi Miyagi, Shinji Nagata, Futoshi Mihara, Mayu Ohshio, Tomio Sasaki

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This study aimed to assess the relevance of epilepsy and spina bifida in the lumbosacral region. We evaluated 75 patients with spina bifida admitted to the Kyushu University Hospital from 1980 to 2004. Patients were classified as having meningocele (MC, 4 cases), myelomeningocele (MMC, 6), myeloschisis (MS, 45), and lumbosacral lipoma (LL, 20). Nine cases had epileptic disorders, and all showed MS. Meticulous neuroradiological investigations revealed cerebral abnormalities such as polymicrogyria or hypogenesis of the corpus callosum in all epileptic cases. Locations of cerebral abnormalities topographically correlated with areas of interictal EEG abnormalities. Although all epileptic cases had ventriculoperitoneal (VP) shunt for hydrocephalus before the onset of epilepsy, interictal EEG abnormalities could not be explained by location of the VP shunt. In all LL patients, neither history of epilepsy nor cerebral abnormalities were noted on magnetic resonance imaging (MRI). Epileptogenesis in spina bifida patients seemed to correlate with coexisting cerebral abnormalities in MS patients rather than with the VP shunt. However, not all spina bifida patients associated with cerebral abnormalities had epilepsy, and not all cerebral abnormalities were epileptogenic, suggesting that epilepsy in spina bifida patients was multifactorial.

Original languageEnglish
Pages (from-to)327-332
Number of pages6
JournalNeurosurgical Review
Volume29
Issue number4
DOIs
Publication statusPublished - Oct 1 2006

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Lumbosacral Region
Spinal Dysraphism
Epilepsy
Ventriculoperitoneal Shunt
Electroencephalography
Meningocele
Agenesis of Corpus Callosum
Meningomyelocele
Lipoma
Hydrocephalus
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Yoshida, F., Morioka, T., Hashiguchi, K., Kawamura, T., Miyagi, Y., Nagata, S., ... Sasaki, T. (2006). Epilepsy in patients with spina bifida in the lumbosacral region. Neurosurgical Review, 29(4), 327-332. https://doi.org/10.1007/s10143-006-0035-7

Epilepsy in patients with spina bifida in the lumbosacral region. / Yoshida, Fumiaki; Morioka, Takato; Hashiguchi, Kimiaki; Kawamura, Tadao; Miyagi, Yasushi; Nagata, Shinji; Mihara, Futoshi; Ohshio, Mayu; Sasaki, Tomio.

In: Neurosurgical Review, Vol. 29, No. 4, 01.10.2006, p. 327-332.

Research output: Contribution to journalArticle

Yoshida, F, Morioka, T, Hashiguchi, K, Kawamura, T, Miyagi, Y, Nagata, S, Mihara, F, Ohshio, M & Sasaki, T 2006, 'Epilepsy in patients with spina bifida in the lumbosacral region', Neurosurgical Review, vol. 29, no. 4, pp. 327-332. https://doi.org/10.1007/s10143-006-0035-7
Yoshida F, Morioka T, Hashiguchi K, Kawamura T, Miyagi Y, Nagata S et al. Epilepsy in patients with spina bifida in the lumbosacral region. Neurosurgical Review. 2006 Oct 1;29(4):327-332. https://doi.org/10.1007/s10143-006-0035-7
Yoshida, Fumiaki ; Morioka, Takato ; Hashiguchi, Kimiaki ; Kawamura, Tadao ; Miyagi, Yasushi ; Nagata, Shinji ; Mihara, Futoshi ; Ohshio, Mayu ; Sasaki, Tomio. / Epilepsy in patients with spina bifida in the lumbosacral region. In: Neurosurgical Review. 2006 ; Vol. 29, No. 4. pp. 327-332.
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