Epitope mapping of CD1a, CD1b, and CD1c antigens in human skin: Differential localization on langerhans cells, keratinocytes, and basement membrane zone

Masutaka Furue, Margit Nindl, Katsura Kawabe, Koichiro Nakamura, Yasumasa Ishibashi, Kimitaka Sagawa

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

CD1 antigens are classified into at least three groups, CD1a, CD1b, and CD1c. In order to delineate the localization of epitopes of CD 1 antigens in human skin, we examined the immunoreactivity of fourteen different CD1 antibodies (seven CDla, five CD1b, and two CD1c antibodies). The epitopes for CD1a, CD1b, and CD1c are differentially localized on epidermal Langerhans cells, dermal dendritic cells, keratinocytes, the luminal portion of eccrine gland ducts, and the basement membrane zone in normal human skin.

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalJournal of Investigative Dermatology
Volume99
Issue number5
DOIs
Publication statusPublished - Nov 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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