Epitope mapping of CD1a, CD1b, and CD1c antigens in human skin: Differential localization on Langerhans cells, keratinocytes, and basement membrane zone

M. Furue, M. Nindl, K. Kawabe, K. Nakamura, Y. Ishibashi, K. Sagawa

Research output: Contribution to journalArticle

Abstract

CD1 antigens are classified into at least three groups, CD1a, CD1b, and CD1c. In order to delineate the localization of epitopes of CD1 antigens in human skin, we examined the immunoreactivity of fourteen different CD1 antibodies (seven CD1a, five CD1b, and two CD1c antibodies). The epitopes for CD1a, CD1b, and CD1c are differentially localized on epidermal Langerhans cells, dermal dendritic cells, keratinocytes, the luminal portion of eccrine gland ducts, and the basement membrane zone in normal human skin.

Original languageEnglish
JournalJournal of Investigative Dermatology
Volume99
Issue number5
Publication statusPublished - Jan 1 1992
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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