Epstein-Barr virus-associated lymphoproliferative disease after a cord blood transplant for Diamond-Blackfan anemia

Shoichi Ohga, Y. Kanaya, H. Maki, Hidetoshi Takada, K. Ohshima, M. Kanda, A. Nomura, A. Suminoe, A. Matsuzaki, T. Hara

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A 7-year-old boy with Diamond-Blackfan anemia (DBA) developed lymphoproliferative disease (LPD) after a cord blood transplant (CBT). 3.1 x 10 7 /kg mononuclear cells from an HLA one-locus mismatched CB were transplanted after conditioning with total body irradiation (8 Gy), cyclophosphamide (200 mg/kg) and antithymocyte globulin (10 mg/kg). Complete engraftment occurred on day 33 post transplant. Despite the resolution of grade II graft-versus-host disease (GVHD), he died of lymphoma on day 130 post transplant. The tumor was of donor origin, indicating clonal proliferation of Epstein-Barr virus (EBV)-infected B cells. This is the first report of EBV-LPD after CBT. Post-transplant LPD can be a serious EBV-associated complication of CB grafts.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalBone Marrow Transplantation
Volume25
Issue number2
DOIs
Publication statusPublished - Jan 1 2000

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Diamond-Blackfan Anemia
Human Herpesvirus 4
Fetal Blood
Transplants
Antilymphocyte Serum
Whole-Body Irradiation
Graft vs Host Disease
Virus Diseases
Cyclophosphamide
Lymphoma
B-Lymphocytes
Tissue Donors

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Epstein-Barr virus-associated lymphoproliferative disease after a cord blood transplant for Diamond-Blackfan anemia. / Ohga, Shoichi; Kanaya, Y.; Maki, H.; Takada, Hidetoshi; Ohshima, K.; Kanda, M.; Nomura, A.; Suminoe, A.; Matsuzaki, A.; Hara, T.

In: Bone Marrow Transplantation, Vol. 25, No. 2, 01.01.2000, p. 209-212.

Research output: Contribution to journalArticle

Ohga, S, Kanaya, Y, Maki, H, Takada, H, Ohshima, K, Kanda, M, Nomura, A, Suminoe, A, Matsuzaki, A & Hara, T 2000, 'Epstein-Barr virus-associated lymphoproliferative disease after a cord blood transplant for Diamond-Blackfan anemia', Bone Marrow Transplantation, vol. 25, no. 2, pp. 209-212. https://doi.org/10.1038/sj.bmt.1702138
Ohga, Shoichi ; Kanaya, Y. ; Maki, H. ; Takada, Hidetoshi ; Ohshima, K. ; Kanda, M. ; Nomura, A. ; Suminoe, A. ; Matsuzaki, A. ; Hara, T. / Epstein-Barr virus-associated lymphoproliferative disease after a cord blood transplant for Diamond-Blackfan anemia. In: Bone Marrow Transplantation. 2000 ; Vol. 25, No. 2. pp. 209-212.
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