Epstein-Barr virus - Associated meningoencephalomyelitis: Intrathecal reactivation of the virus in an immunocompetent child

Masafumi Sanefuji, Shouichi Ohga, Ryutaro Kira, Akihiko Nomura, Hiroyuki Torisu, Hidetoshi Takada, Koichi Kusuhara, Toshiro Hara

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Neurologic complications, including meningoencephalitis, transverse myelitis, and peripheral neuropathy, have been reported in patients with acute infectious mononucleosis. Chronic active Epstein-Barr virus and human immunodeficiency virus infections occasionally induce central nervous system lymphoma. On the other hand, central nervous system disease alone associated with Epstein-Barr virus rarely occurs in previously healthy individuals. A 15-year-old girl who developed acute disseminated encephalomyelitis-like disease presenting fever, anuresis, diplopia, and muscle weakness is described here. Clinical and neuroimaging studies led to the diagnosis of encephalomyelitis. Despite the absence of infectious mononucleosis-like symptoms, anti-Epstein-Barr virus antibody titers in serum and cerebrospinal fluid showed the virus reactivation. The copy number of Epstein-Barr virus DNA increased in cerebrospinal fluid but not in peripheral blood. Ganciclovir and repeated methyl-prednisolone pulse therapy resulted in complete resolution. Central nervous system disease on the limited intrathecal reactivation of Epstein-Barr virus in immunocompetent children should be differentiated from acute disseminated encephalomyelitis.

Original languageEnglish
Pages (from-to)1072-1077
Number of pages6
JournalJournal of Child Neurology
Volume23
Issue number9
DOIs
Publication statusPublished - Sep 3 2008

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Human Herpesvirus 4
Viruses
Acute Disseminated Encephalomyelitis
Infectious Mononucleosis
Central Nervous System Diseases
Cerebrospinal Fluid
Transverse Myelitis
Encephalomyelitis
Ganciclovir
Meningoencephalitis
Diplopia
Muscle Weakness
Peripheral Nervous System Diseases
Virus Diseases
Prednisolone
Viral Load
Neuroimaging
Nervous System
Lymphoma
Fever

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Epstein-Barr virus - Associated meningoencephalomyelitis : Intrathecal reactivation of the virus in an immunocompetent child. / Sanefuji, Masafumi; Ohga, Shouichi; Kira, Ryutaro; Nomura, Akihiko; Torisu, Hiroyuki; Takada, Hidetoshi; Kusuhara, Koichi; Hara, Toshiro.

In: Journal of Child Neurology, Vol. 23, No. 9, 03.09.2008, p. 1072-1077.

Research output: Contribution to journalArticle

Sanefuji, Masafumi ; Ohga, Shouichi ; Kira, Ryutaro ; Nomura, Akihiko ; Torisu, Hiroyuki ; Takada, Hidetoshi ; Kusuhara, Koichi ; Hara, Toshiro. / Epstein-Barr virus - Associated meningoencephalomyelitis : Intrathecal reactivation of the virus in an immunocompetent child. In: Journal of Child Neurology. 2008 ; Vol. 23, No. 9. pp. 1072-1077.
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