Epstein-barr virus load in cerebrospinal fluid of patients with chronic active epstein-barr virus infection

Shouichi Ohga; Masafumi Sanefuji; Masataka Ishimura; Akihiko Nomura; Hiroyuki Torisu; Ryutaro Kira; Hidetoshi Takada; Yumi Mizuno; Yukumasa Kazuyama; Toshiro Hara

doi:10.1097/INF.0b013e318178d21e

Epstein-barr virus load in cerebrospinal fluid of patients with chronic active epstein-barr virus infection

Shouichi Ohga, Masafumi Sanefuji, Masataka Ishimura, Akihiko Nomura, Hiroyuki Torisu, Ryutaro Kira, Hidetoshi Takada, Yumi Mizuno, Yukumasa Kazuyama, Toshiro Hara

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Chronic active Epstein-Barr virus (EBV) infection is a rare chronic mononucleosis syndrome involving clonally proliferating EBV-infected T-/NK-cells. EBV DNA was quantified in nonpleocytotic cerebrospinal fluid (CSF) of 9 patients. Three patients with neurologic and/or neuroimaging abnormalities showed high CSF copy numbers. In 1 patient, CSF copy number exceeded the peripheral blood value. CSF EBV-load may predict the central nervous system involvement of EBVT-/NK-cells.

Original language	English
Pages (from-to)	1027-1030
Number of pages	4
Journal	Pediatric Infectious Disease Journal
Volume	27
Issue number	11
DOIs	https://doi.org/10.1097/INF.0b013e318178d21e
Publication status	Published - Nov 2008

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/INF.0b013e318178d21e

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title = "Epstein-barr virus load in cerebrospinal fluid of patients with chronic active epstein-barr virus infection",

abstract = "Chronic active Epstein-Barr virus (EBV) infection is a rare chronic mononucleosis syndrome involving clonally proliferating EBV-infected T-/NK-cells. EBV DNA was quantified in nonpleocytotic cerebrospinal fluid (CSF) of 9 patients. Three patients with neurologic and/or neuroimaging abnormalities showed high CSF copy numbers. In 1 patient, CSF copy number exceeded the peripheral blood value. CSF EBV-load may predict the central nervous system involvement of EBVT-/NK-cells.",

author = "Shouichi Ohga and Masafumi Sanefuji and Masataka Ishimura and Akihiko Nomura and Hiroyuki Torisu and Ryutaro Kira and Hidetoshi Takada and Yumi Mizuno and Yukumasa Kazuyama and Toshiro Hara",

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doi = "10.1097/INF.0b013e318178d21e",

language = "English",

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T1 - Epstein-barr virus load in cerebrospinal fluid of patients with chronic active epstein-barr virus infection

AU - Ohga, Shouichi

AU - Sanefuji, Masafumi

AU - Ishimura, Masataka

AU - Nomura, Akihiko

AU - Torisu, Hiroyuki

AU - Kira, Ryutaro

AU - Takada, Hidetoshi

AU - Mizuno, Yumi

AU - Kazuyama, Yukumasa

AU - Hara, Toshiro

PY - 2008/11

Y1 - 2008/11

N2 - Chronic active Epstein-Barr virus (EBV) infection is a rare chronic mononucleosis syndrome involving clonally proliferating EBV-infected T-/NK-cells. EBV DNA was quantified in nonpleocytotic cerebrospinal fluid (CSF) of 9 patients. Three patients with neurologic and/or neuroimaging abnormalities showed high CSF copy numbers. In 1 patient, CSF copy number exceeded the peripheral blood value. CSF EBV-load may predict the central nervous system involvement of EBVT-/NK-cells.

AB - Chronic active Epstein-Barr virus (EBV) infection is a rare chronic mononucleosis syndrome involving clonally proliferating EBV-infected T-/NK-cells. EBV DNA was quantified in nonpleocytotic cerebrospinal fluid (CSF) of 9 patients. Three patients with neurologic and/or neuroimaging abnormalities showed high CSF copy numbers. In 1 patient, CSF copy number exceeded the peripheral blood value. CSF EBV-load may predict the central nervous system involvement of EBVT-/NK-cells.

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ER -

Epstein-barr virus load in cerebrospinal fluid of patients with chronic active epstein-barr virus infection

Abstract

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