Epstein-Barr virus-positive diffuse large B-cell primary central nervous system lymphoma associated with organized chronic subdural hematoma: A case report and review of the literature

Katsuharu Kameda, Tadahisa Shono, Soh Takagishi, Shinji Kono, Takatoshi Aoki, Yoshikiyo Ito, Tomohiko Kamimura, Yasuo Sugita, Koichi Ohshima

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Abstract

We here report on a rare case of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) detected in both brain parenchyma and in an organized chronic subdural hematoma (OCSH). A 96-year-old man diagnosed with asymptomatic OCSH in the left frontal convexity was referred to our hospital because of a de novo mass lesion just beneath the OCSH on contrast-enhanced magnetic resonance imaging. The size of the OCSH remained stable. We diagnosed the lesion as a malignant tumor. At surgery, the organized hematoma and the soft fragile tumor were removed. Histological examinations revealed pleomorphic lymphoid cells not only in the brain tissue but also in the OCSH component with tumor necrosis, and these were immunopositive for B-cell markers. In situ hybridization revealed positive signals for EBV-encoded small RNAs, consistent with EBV-positive DLBCL. Since the membranes of the subdural hematoma were fibrous and the tumor progression resulted in necrosis of the tumor, the DLBCL may have originally developed in the OCSH and infiltrated into the brain parenchyma. We believe that this rare case provides crucial information for the understanding of DLBCLs associated with OCSH.

Original languageEnglish
Pages (from-to)138-143
Number of pages6
JournalPathology International
Volume65
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

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Hematoma, Subdural, Chronic
Human Herpesvirus 4
Lymphoma
B-Lymphocytes
Central Nervous System
Lymphoma, Large B-Cell, Diffuse
Neoplasms
Brain
Necrosis
Subdural Hematoma
Hematoma
In Situ Hybridization
Magnetic Resonance Imaging
Lymphocytes
RNA
Membranes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Epstein-Barr virus-positive diffuse large B-cell primary central nervous system lymphoma associated with organized chronic subdural hematoma : A case report and review of the literature. / Kameda, Katsuharu; Shono, Tadahisa; Takagishi, Soh; Kono, Shinji; Aoki, Takatoshi; Ito, Yoshikiyo; Kamimura, Tomohiko; Sugita, Yasuo; Ohshima, Koichi.

In: Pathology International, Vol. 65, No. 3, 01.03.2015, p. 138-143.

Research output: Contribution to journalArticle

Kameda, Katsuharu ; Shono, Tadahisa ; Takagishi, Soh ; Kono, Shinji ; Aoki, Takatoshi ; Ito, Yoshikiyo ; Kamimura, Tomohiko ; Sugita, Yasuo ; Ohshima, Koichi. / Epstein-Barr virus-positive diffuse large B-cell primary central nervous system lymphoma associated with organized chronic subdural hematoma : A case report and review of the literature. In: Pathology International. 2015 ; Vol. 65, No. 3. pp. 138-143.
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