Equarin, a novel soluble molecule expressed with polarity at chick embryonic lens equator, is involved in eye formation

Hong Mu, Kunimasa Ohta, Sei Kuriyama, Naoko Shimada, Hidenobu Tanihara, Kunio Yasuda, Hideaki Tanaka

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The lens plays an important role in eye development. To investigate the molecular mechanisms involved, we used signal sequence trap screens with a chicken lens cDNA library and identified a novel secreted molecule, equarin. Equarin encodes consensus repeat domains conserved in human SRPX and mouse Urb. In the embryonic eye, equarin transcript is detected exclusively in the lens, and persists in the lens equatorial region in a high-dorsal-to-low-ventral gradient. In vitro analysis of equarin protein indicated that after translation, it is modified, cleaved, and secreted to extracellular locations. Microinjection of equarin mRNA into Xenopus embryos induced abnormal eye development. These data suggest that equarin is involved in eye formation.

Original languageEnglish
Pages (from-to)143-155
Number of pages13
JournalMechanisms of Development
Volume120
Issue number2
DOIs
Publication statusPublished - Feb 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Embryology
  • Developmental Biology

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