Abstract
Silyl enol ethers derived from substituted cyclohexanones are ethenylated with trimethylsilylethyne in the presence of GaCl3. Carbon-carbon bond formation was completed in less than 5 min at room temperature and protodegallation of the organogallium intermediate formed with 6 M sulfuric acid gave β-enones. The reactions exhibit a bias for the equatorial C-C bond formation, which contrasts the axial stereochemistry of enolate alkylation. The origin of this stereoselectivity is discussed.
Original language | English |
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Pages (from-to) | 138-145 |
Number of pages | 8 |
Journal | Synthesis |
Issue number | 1 |
DOIs | |
Publication status | Published - 2002 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Catalysis
- Organic Chemistry