Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice

I. Chian Lin, Shuya Yamashita, Motoki Murata, Motofumi Kumazoe, Hirofumi Tachibana

Research output: Contribution to journalArticle

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Abstract

Rheumatoid arthritis (RA) is a chronic and systemic autoimmune inflammatory disease. Typical pathological findings of RA include persistent synovitis and bone degradation in the peripheral joints. Equol, a metabolite of the major soybean isoflavone daidzein, shows superior bioactivity than other isoflavones. We investigated the effects of equol administration on inflammatory response and bone erosion in mice with collagen-induced arthritis (CIA). The severity of arthritis symptoms was significantly low in the equol-administered CIA mice. In addition, equol administration improved the CIA-induced bone mineral density decline. In the inflamed area of CIA mice, equol administration suppressed the expression of interleukin-6 and its receptor. Furthermore, equol reduced the expression of genes associated with bone formation inhibition, osteoclast and immature osteoblast specificity and cartilage destruction. These results suggest that equol suppresses RA development and RA-induced bone erosion by regulating inflammation and bone metabolism.

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalJournal of Nutritional Biochemistry
Volume32
DOIs
Publication statusPublished - Jun 1 2016

Fingerprint

Equol
Erosion
Rheumatoid Arthritis
Bone
Experimental Arthritis
Bone and Bones
Collagen
Isoflavones
Interleukin-6 Receptors
Osteitis
Synovitis
Osteoblasts
Cartilage
Osteoclasts
Metabolites
Bioactivity
Soybeans
Metabolism
Osteogenesis
Bone Density

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice. / Lin, I. Chian; Yamashita, Shuya; Murata, Motoki; Kumazoe, Motofumi; Tachibana, Hirofumi.

In: Journal of Nutritional Biochemistry, Vol. 32, 01.06.2016, p. 101-106.

Research output: Contribution to journalArticle

Lin, I. Chian ; Yamashita, Shuya ; Murata, Motoki ; Kumazoe, Motofumi ; Tachibana, Hirofumi. / Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice. In: Journal of Nutritional Biochemistry. 2016 ; Vol. 32. pp. 101-106.
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