Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin

Yasunobu Abe, Shinji Yashiki, Ilseung Choi, Keiichi Hara, Takamitsu Matsushima, Junji Nishimura, Shoichi Inaba, Hajime Nawata, Koichiro Muta

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15 Citations (Scopus)

Abstract

We describe the case of a 55-year-old man with adult T-cell leukemia/lymphoma (ATL) in first remission who underwent nonmyeloablative allogeneic peripheral blood stem cell transplantation with conditioning consisting of 4 courses of pentostatin and low-dose total body irradiation. Complete chimerism in peripheral blood was achieved on day 42 without severe myelosuppression. Concomitantly, the proviral DNA load for human T-cell leukemia virus I (HTLV-I) in peripheral blood mononuclear cells decreased below detectable limits and was still undetectable on day 270. This fact indicates that eradication of ATL cells is feasible by induction of an alloimmune response without high-dose chemoradiotherapy.

Original languageEnglish
Pages (from-to)91-93
Number of pages3
JournalInternational journal of hematology
Volume76
Issue number1
DOIs
Publication statusPublished - Jul 1 2002

All Science Journal Classification (ASJC) codes

  • Hematology

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