Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin

Yasunobu Abe; Shinji Yashiki; Ilseung Choi; Keiichi Hara; Takamitsu Matsushima; Junji Nishimura; Shoichi Inaba; Hajime Nawata; Koichiro Muta

doi:10.1007/BF02982725

Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin

Yasunobu Abe, Shinji Yashiki, Ilseung Choi, Keiichi Hara, Takamitsu Matsushima, Junji Nishimura, Shoichi Inaba, Hajime Nawata, Koichiro Muta

Internal Medicine

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We describe the case of a 55-year-old man with adult T-cell leukemia/lymphoma (ATL) in first remission who underwent nonmyeloablative allogeneic peripheral blood stem cell transplantation with conditioning consisting of 4 courses of pentostatin and low-dose total body irradiation. Complete chimerism in peripheral blood was achieved on day 42 without severe myelosuppression. Concomitantly, the proviral DNA load for human T-cell leukemia virus I (HTLV-I) in peripheral blood mononuclear cells decreased below detectable limits and was still undetectable on day 270. This fact indicates that eradication of ATL cells is feasible by induction of an alloimmune response without high-dose chemoradiotherapy.

Original language	English
Pages (from-to)	91-93
Number of pages	3
Journal	International journal of hematology
Volume	76
Issue number	1
DOIs	https://doi.org/10.1007/BF02982725
Publication status	Published - Jul 2002

All Science Journal Classification (ASJC) codes

Hematology

Access to Document

10.1007/BF02982725

Fingerprint

Dive into the research topics of 'Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin'. Together they form a unique fingerprint.

Cite this

Abe, Y., Yashiki, S., Choi, I., Hara, K., Matsushima, T., Nishimura, J., Inaba, S., Nawata, H., & Muta, K. (2002). Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin. International journal of hematology, 76(1), 91-93. https://doi.org/10.1007/BF02982725

Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin. / Abe, Yasunobu; Yashiki, Shinji; Choi, Ilseung et al.
In: International journal of hematology, Vol. 76, No. 1, 07.2002, p. 91-93.

Research output: Contribution to journal › Article › peer-review

Abe, Y, Yashiki, S, Choi, I, Hara, K, Matsushima, T, Nishimura, J, Inaba, S, Nawata, H & Muta, K 2002, 'Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin', International journal of hematology, vol. 76, no. 1, pp. 91-93. https://doi.org/10.1007/BF02982725

Abe Y, Yashiki S, Choi I, Hara K, Matsushima T, Nishimura J et al. Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin. International journal of hematology. 2002 Jul;76(1):91-93. doi: 10.1007/BF02982725

@article{dc05b8801e6d4121868c2910b8b3173d,

title = "Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin",

abstract = "We describe the case of a 55-year-old man with adult T-cell leukemia/lymphoma (ATL) in first remission who underwent nonmyeloablative allogeneic peripheral blood stem cell transplantation with conditioning consisting of 4 courses of pentostatin and low-dose total body irradiation. Complete chimerism in peripheral blood was achieved on day 42 without severe myelosuppression. Concomitantly, the proviral DNA load for human T-cell leukemia virus I (HTLV-I) in peripheral blood mononuclear cells decreased below detectable limits and was still undetectable on day 270. This fact indicates that eradication of ATL cells is feasible by induction of an alloimmune response without high-dose chemoradiotherapy.",

author = "Yasunobu Abe and Shinji Yashiki and Ilseung Choi and Keiichi Hara and Takamitsu Matsushima and Junji Nishimura and Shoichi Inaba and Hajime Nawata and Koichiro Muta",

year = "2002",

month = jul,

doi = "10.1007/BF02982725",

language = "English",

volume = "76",

pages = "91--93",

journal = "International Journal of Hematology",

issn = "0925-5710",

publisher = "Springer Japan",

number = "1",

}

TY - JOUR

T1 - Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin

AU - Abe, Yasunobu

AU - Yashiki, Shinji

AU - Choi, Ilseung

AU - Hara, Keiichi

AU - Matsushima, Takamitsu

AU - Nishimura, Junji

AU - Inaba, Shoichi

AU - Nawata, Hajime

AU - Muta, Koichiro

PY - 2002/7

Y1 - 2002/7

N2 - We describe the case of a 55-year-old man with adult T-cell leukemia/lymphoma (ATL) in first remission who underwent nonmyeloablative allogeneic peripheral blood stem cell transplantation with conditioning consisting of 4 courses of pentostatin and low-dose total body irradiation. Complete chimerism in peripheral blood was achieved on day 42 without severe myelosuppression. Concomitantly, the proviral DNA load for human T-cell leukemia virus I (HTLV-I) in peripheral blood mononuclear cells decreased below detectable limits and was still undetectable on day 270. This fact indicates that eradication of ATL cells is feasible by induction of an alloimmune response without high-dose chemoradiotherapy.

AB - We describe the case of a 55-year-old man with adult T-cell leukemia/lymphoma (ATL) in first remission who underwent nonmyeloablative allogeneic peripheral blood stem cell transplantation with conditioning consisting of 4 courses of pentostatin and low-dose total body irradiation. Complete chimerism in peripheral blood was achieved on day 42 without severe myelosuppression. Concomitantly, the proviral DNA load for human T-cell leukemia virus I (HTLV-I) in peripheral blood mononuclear cells decreased below detectable limits and was still undetectable on day 270. This fact indicates that eradication of ATL cells is feasible by induction of an alloimmune response without high-dose chemoradiotherapy.

UR - http://www.scopus.com/inward/record.url?scp=0036632910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036632910&partnerID=8YFLogxK

U2 - 10.1007/BF02982725

DO - 10.1007/BF02982725

M3 - Article

C2 - 12138903

AN - SCOPUS:0036632910

SN - 0925-5710

VL - 76

SP - 91

EP - 93

JO - International Journal of Hematology

JF - International Journal of Hematology

IS - 1

ER -

Eradication of virus-infected T-cells in a case of adult T-cell leukemia/lymphoma by nonmyeloablative peripheral blood stem cell transplantation with conditioning consisting of low-dose total body irradiation and pentostatin

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this