TY - JOUR
T1 - Escherichia coli O8:H8 Carrying a novel variant of the heat-labile enterotoxin LT2 gene caused outbreaks of diarrhea
AU - Ishimaru, Kai
AU - Sasaki, Mari
AU - Narimatsu, Hiroshi
AU - Arimizu, Yoko
AU - Gotoh, Yasuhiro
AU - Nakamura, Keiji
AU - Hayashi, Tetsuya
AU - Ogura, Yoshitoshi
N1 - Funding Information:
Financial support. This work was funded by JSPS KAKENHI under grant numbers 16H06279 and 17H04077 to Y.O. and 16H05190 to T.H. and by AMED under grant numbers JP17efk0108127h0002 to Y.O. and 18fk0108065h0801 to T.H.
Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
PY - 2020/1/1
Y1 - 2020/1/1
N2 - No outbreaks caused by Escherichia coli-producing heat-labile enterotoxin LT2 have been reported to date. Here, we revealed that the E. coli O8:H8 strains isolated from patients in 2 independent diarrhea outbreaks were negative for any known virulence determinants in routine microbiological tests, were very closely related, and carried a prophage-encoded gene for a novel LT2 variant (LT2d) and the genes for colonization factor antigen III. We also showed that LT2d has a cytotonic activity similar to LT1. These data indicate the importance of E. coli strains producing LT2d as a human pathogen.
AB - No outbreaks caused by Escherichia coli-producing heat-labile enterotoxin LT2 have been reported to date. Here, we revealed that the E. coli O8:H8 strains isolated from patients in 2 independent diarrhea outbreaks were negative for any known virulence determinants in routine microbiological tests, were very closely related, and carried a prophage-encoded gene for a novel LT2 variant (LT2d) and the genes for colonization factor antigen III. We also showed that LT2d has a cytotonic activity similar to LT1. These data indicate the importance of E. coli strains producing LT2d as a human pathogen.
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U2 - 10.1093/ofid/ofaa021
DO - 10.1093/ofid/ofaa021
M3 - Article
AN - SCOPUS:85081585438
VL - 7
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
SN - 2328-8957
IS - 1
ER -
