Escherichia coli O8:H8 Carrying a novel variant of the heat-labile enterotoxin LT2 gene caused outbreaks of diarrhea

Kai Ishimaru, Mari Sasaki, Hiroshi Narimatsu, Yoko Arimizu, Yasuhiro Gotoh, Keiji Nakamura, Tetsuya Hayashi, Yoshitoshi Ogura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

No outbreaks caused by Escherichia coli-producing heat-labile enterotoxin LT2 have been reported to date. Here, we revealed that the E. coli O8:H8 strains isolated from patients in 2 independent diarrhea outbreaks were negative for any known virulence determinants in routine microbiological tests, were very closely related, and carried a prophage-encoded gene for a novel LT2 variant (LT2d) and the genes for colonization factor antigen III. We also showed that LT2d has a cytotonic activity similar to LT1. These data indicate the importance of E. coli strains producing LT2d as a human pathogen.

Original languageEnglish
JournalOpen Forum Infectious Diseases
Volume7
Issue number1
DOIs
Publication statusPublished - Jan 1 2020

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology

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