Esophageal motility and psychiatric factors in functional dyspepsia patients with or without pain

Masanori Handa, Kazunori Mine, Hiroshi Yamamoto, Shinichi Tsutsui, Haruo Hayashi, Naoko Kinukawa, Chiharu Kubo

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Subtypes of functional dyspepsia (FD), including refluxlike dyspepsia, ulcerlike dyspepsia, dysmotility-like dyspepsia, and nonspecific dyspepsia, have been described and are widely used clinically. However, these symptom patterns often overlap, and the terms are insufficient for indicating all FD symptoms. In this study, we divided 71 FD patients into two groups: patients with or without pain. Group I, the pain dyspepsia group, included patients in whom the main symptoms were epigastralgia and/or chest pain. Group II, the painless dyspepsia group, included patients without pain, in whom the symptoms were nausea, vomiting, and heartburn. We examined the relationship between esophageal function and psychiatric factors in the test groups and compared them with a control group. Of the FD patients, 19.7% [8 (25%) of 32 group I patients, 6 (15.4%) of 39 group II patients] had esophageal motility disorders, such as nutcracker esophagus and diffuse esophageal spasm. The LES pressure of group I was higher than that of group II by esophageal manometry (P < 0.05). In 17 (53.1%) of 32 group I patients and 31 (79.5%) of 39 group II patients, psychiatric disorders (38.0% had depressive disorder and 21.1% had an anxiety disorder) were diagnosed following DSM III-R criteria. Group II tended to be more depressive than group I (P = 0.0508). Psychological assessment scores, STAI-I and STAI-II, were higher in groups I and II than in the control group (P < 0.001). Long-term distress, anxiety, and depression seem to influence the symptoms of FD patients. Esophageal dysmotility may be an important functional abnormality of FD.

Original languageEnglish
Pages (from-to)2094-2098
Number of pages5
JournalDigestive Diseases and Sciences
Volume44
Issue number10
DOIs
Publication statusPublished - Nov 11 1999

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Dyspepsia
Psychiatry
Pain
Esophageal Motility Disorders
Diffuse Esophageal Spasm
Heartburn
Control Groups
Manometry
Depressive Disorder
Anxiety Disorders
Chest Pain
Diagnostic and Statistical Manual of Mental Disorders
Nausea
Vomiting
Anxiety
Depression
Psychology

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Esophageal motility and psychiatric factors in functional dyspepsia patients with or without pain. / Handa, Masanori; Mine, Kazunori; Yamamoto, Hiroshi; Tsutsui, Shinichi; Hayashi, Haruo; Kinukawa, Naoko; Kubo, Chiharu.

In: Digestive Diseases and Sciences, Vol. 44, No. 10, 11.11.1999, p. 2094-2098.

Research output: Contribution to journalArticle

Handa, Masanori ; Mine, Kazunori ; Yamamoto, Hiroshi ; Tsutsui, Shinichi ; Hayashi, Haruo ; Kinukawa, Naoko ; Kubo, Chiharu. / Esophageal motility and psychiatric factors in functional dyspepsia patients with or without pain. In: Digestive Diseases and Sciences. 1999 ; Vol. 44, No. 10. pp. 2094-2098.
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