Establishment and characterization of PTHrP-producing human pancreatic cancer cell line

Y. Nishi, M. Haji, R. Takayanagi, H. Iguchi, T. Shimazoe, J. Hirata, H. Nawata

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Human pancreatic ductal cell carcinoma cell line, which can secrete parathyroid hormone-related peptide (PTHrP), designated as KP 4, and its daughter cell lines with different PTHrP-secreting activities, termed KP 4-1 and KP 4-2, have been established in tissue culture. KP 4 cells were able to form tumors in nude mice. The absolute production rate of PTHrP in KP 4-1 was 5 to 10 times higher than that in KP 4-2. Similarly, the level of PTHrP mRNA in KP 4-1 was significantly higher than that in KP 4-2. KP 4-2 cells exhibited more rapid growth than KP 4 and KP 4-2 vitro. Our established cell lines should provide a useful system to study the regulation of PTHrP production and its pathophysiological roles.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalInternational journal of oncology
Volume5
Issue number1
DOIs
Publication statusPublished - 1994

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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