Establishment of a Feline T-Lymphoblastoid Cell Line Susceptible to Feline Immunodeficiency Viruses

Satoshi Fujimoto, Mahito Masuda, Etsuro Ono, Hiroshi Kida, Yukio Shimizu

Research output: Contribution to journalArticle

Abstract

A feline T-lymphoblastoid cell line susceptible to feline immunodeficiency viruses (FIV) was established and designated as Yu-1 cells. Yu-1 cells continued to grow over one year with more than 100 successive passages in the presence of human recombinant interleukin-2. Surface antigens of Yu-1 cells were feline Pan-T+, CD4+, and CD8-. Susceptibility of Yu-1 cells to FIV strains were higher than that of the primary culture of the feline peripheral blood mononuclear cells, indicating that this cell line should be useful for isolation, propagation, and neutralization test of FIV.

Original languageEnglish
Pages (from-to)774-777
Number of pages4
JournalMICROBIOLOGY and IMMUNOLOGY
Volume37
Issue number5
Publication statusPublished - Jan 1 1993

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Feline Immunodeficiency Virus
Felidae
Cell Line
Neutralization Tests
Surface Antigens
Interleukin-2
Blood Cells

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

Cite this

Establishment of a Feline T-Lymphoblastoid Cell Line Susceptible to Feline Immunodeficiency Viruses. / Fujimoto, Satoshi; Masuda, Mahito; Ono, Etsuro; Kida, Hiroshi; Shimizu, Yukio.

In: MICROBIOLOGY and IMMUNOLOGY, Vol. 37, No. 5, 01.01.1993, p. 774-777.

Research output: Contribution to journalArticle

Fujimoto, Satoshi ; Masuda, Mahito ; Ono, Etsuro ; Kida, Hiroshi ; Shimizu, Yukio. / Establishment of a Feline T-Lymphoblastoid Cell Line Susceptible to Feline Immunodeficiency Viruses. In: MICROBIOLOGY and IMMUNOLOGY. 1993 ; Vol. 37, No. 5. pp. 774-777.
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