Establishment of a new human uterine cervical adenocarcinoma cell line, SiSo, and its: Reactivity to anti-cancer reagents

K. Sonoda, M. Nakashima, T. Saito, S. Amada, T. Kamura, H. Nakano, T. Watanabe

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Abstract

A human cell line, SiSo, was established from a patient afflicted with uterine cervical adenocarcinoma. The SiSo cell expresses MHC class I antigen, various kinds of adhesion molecules and tumor-associated antigens such as CA125, CEA and GA733. The secretion of CA125 antigen was markedly suppressed by anti-cancer reagents. However, their growth was not affected by any of the anti-cancer reagents tested, suggesting a discrepancy between inhibition of tumor growth and suppression of secretion of tumor-associated antigens after treatment with anti-cancer reagents. The SiSo cell line will provide a tool for investigation of uterine adenocarcinoma.

Original languageEnglish
Pages (from-to)1099-1104
Number of pages6
JournalInternational journal of oncology
Volume6
Issue number5
Publication statusPublished - Jan 1 1995

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Sonoda, K., Nakashima, M., Saito, T., Amada, S., Kamura, T., Nakano, H., & Watanabe, T. (1995). Establishment of a new human uterine cervical adenocarcinoma cell line, SiSo, and its: Reactivity to anti-cancer reagents. International journal of oncology, 6(5), 1099-1104.