Establishment of Treatment of Retinal Vein Occlusion by Physical Stimuli of Electrically-Induced Bubbles

Mei Sumimoto; Daisuke Matsumura; Keita Ichikawa; Keiko Miwa; Hideyasu Oh; Yasuhiro Moriizumi; Yoko Yamanishi

doi:10.1109/TRANSDUCERS.2019.8808464

Establishment of Treatment of Retinal Vein Occlusion by Physical Stimuli of Electrically-Induced Bubbles

Mei Sumimoto, Daisuke Matsumura, Keita Ichikawa, Keiko Miwa, Hideyasu Oh, Yasuhiro Moriizumi, Yoko Yamanishi

Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

For this study, a novel treatment of retinal vein occlusion by physical stimuli of electrically-induced bubbles was proposed. Our device can apply local and minimally-invasive physical stimuli to retinal minute blood vessels with a diameter of about 100 μm, utilizing the impact pressure when microbubbles collapse. Furthermore, it is possible to sense the approach of the device to the target by measuring the capacitance. Vascular vessels of chick embryos whose size is similar to that of the retinal vein, and retinal veins of pig were used as in-vitro and in-vivo model respectively. Also, micro-vascular occlusion models were successfully operated and local physical stimuli was applied to the blood clot which is artificially produced. The 60% of reperfusion against the initial amount was confirmed by blood flow measurement for both in vitro and in vivo environment.

Original language	English
Title of host publication	2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	809-812
Number of pages	4
ISBN (Electronic)	9781728120072
DOIs	https://doi.org/10.1109/TRANSDUCERS.2019.8808464
Publication status	Published - Jun 2019
Event	20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII - Berlin, Germany Duration: Jun 23 2019 → Jun 27 2019

Publication series

Name	2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII

Conference

Conference	20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
Country	Germany
City	Berlin
Period	6/23/19 → 6/27/19

All Science Journal Classification (ASJC) codes

Process Chemistry and Technology
Spectroscopy
Electrical and Electronic Engineering
Mechanical Engineering
Electronic, Optical and Magnetic Materials
Control and Optimization
Instrumentation

Access to Document

10.1109/TRANSDUCERS.2019.8808464

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Sumimoto, M., Matsumura, D., Ichikawa, K., Miwa, K., Oh, H., Moriizumi, Y., & Yamanishi, Y. (2019). Establishment of Treatment of Retinal Vein Occlusion by Physical Stimuli of Electrically-Induced Bubbles. In 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII (pp. 809-812). [8808464] (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2019.8808464

Establishment of Treatment of Retinal Vein Occlusion by Physical Stimuli of Electrically-Induced Bubbles. / Sumimoto, Mei; Matsumura, Daisuke; Ichikawa, Keita; Miwa, Keiko; Oh, Hideyasu; Moriizumi, Yasuhiro; Yamanishi, Yoko.

2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII. Institute of Electrical and Electronics Engineers Inc., 2019. p. 809-812 8808464 (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sumimoto, M, Matsumura, D, Ichikawa, K, Miwa, K, Oh, H, Moriizumi, Y & Yamanishi, Y 2019, Establishment of Treatment of Retinal Vein Occlusion by Physical Stimuli of Electrically-Induced Bubbles. in 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII., 8808464, 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, Institute of Electrical and Electronics Engineers Inc., pp. 809-812, 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, Berlin, Germany, 6/23/19. https://doi.org/10.1109/TRANSDUCERS.2019.8808464

Sumimoto M, Matsumura D, Ichikawa K, Miwa K, Oh H, Moriizumi Y et al. Establishment of Treatment of Retinal Vein Occlusion by Physical Stimuli of Electrically-Induced Bubbles. In 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII. Institute of Electrical and Electronics Engineers Inc. 2019. p. 809-812. 8808464. (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII). https://doi.org/10.1109/TRANSDUCERS.2019.8808464

Sumimoto, Mei ; Matsumura, Daisuke ; Ichikawa, Keita ; Miwa, Keiko ; Oh, Hideyasu ; Moriizumi, Yasuhiro ; Yamanishi, Yoko. / Establishment of Treatment of Retinal Vein Occlusion by Physical Stimuli of Electrically-Induced Bubbles. 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 809-812 (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII).

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abstract = "For this study, a novel treatment of retinal vein occlusion by physical stimuli of electrically-induced bubbles was proposed. Our device can apply local and minimally-invasive physical stimuli to retinal minute blood vessels with a diameter of about 100 μm, utilizing the impact pressure when microbubbles collapse. Furthermore, it is possible to sense the approach of the device to the target by measuring the capacitance. Vascular vessels of chick embryos whose size is similar to that of the retinal vein, and retinal veins of pig were used as in-vitro and in-vivo model respectively. Also, micro-vascular occlusion models were successfully operated and local physical stimuli was applied to the blood clot which is artificially produced. The 60% of reperfusion against the initial amount was confirmed by blood flow measurement for both in vitro and in vivo environment.",

author = "Mei Sumimoto and Daisuke Matsumura and Keita Ichikawa and Keiko Miwa and Hideyasu Oh and Yasuhiro Moriizumi and Yoko Yamanishi",

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