Establishment of vertebrate left-right asymmetry

Hiroshi Hamada, Chikara Meno, Daisuke Watanabe, Yukio Saijoh

Research output: Contribution to journalReview article

407 Citations (Scopus)

Abstract

The generation of morphological, such as left-right, asymmetry during development is an integral part of the establishment of a body plan. Until recently, the molecular basis of left-right asymmetry was a mystery, but studies indicate that Nodal and the Lefty proteins, transforming growth factor-β-related molecules, have a central role in generating asymmetric signals. Although the initial mechanism of symmetry breaking remains unknown, developmental biologists are beginning to analyse the pathway that leads to left-right asymmetry establishment and maintenance.

Original languageEnglish
Pages (from-to)103-113
Number of pages11
JournalNature Reviews Genetics
Volume3
Issue number2
DOIs
Publication statusPublished - May 23 2002
Externally publishedYes

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Left-Right Determination Factors
Nodal Protein
Transforming Growth Factors
Vertebrates
Maintenance

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Establishment of vertebrate left-right asymmetry. / Hamada, Hiroshi; Meno, Chikara; Watanabe, Daisuke; Saijoh, Yukio.

In: Nature Reviews Genetics, Vol. 3, No. 2, 23.05.2002, p. 103-113.

Research output: Contribution to journalReview article

Hamada, H, Meno, C, Watanabe, D & Saijoh, Y 2002, 'Establishment of vertebrate left-right asymmetry', Nature Reviews Genetics, vol. 3, no. 2, pp. 103-113. https://doi.org/10.1038/nrg732
Hamada, Hiroshi ; Meno, Chikara ; Watanabe, Daisuke ; Saijoh, Yukio. / Establishment of vertebrate left-right asymmetry. In: Nature Reviews Genetics. 2002 ; Vol. 3, No. 2. pp. 103-113.
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