Estimated half-life of penta-chlorodibenzofuran (PeCDF) and simulation of PeCDF excretion

Manabu Akahane, Shinya Matsumoto, Yoshiyuki Kanagawa, Jumboku Kajiwara, Takashi Todaka, Hironori Hirakawa, Soichi Koike, Masutaka Furue, Tomoaki Imamura

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Abstract

The half-life of 2,3,4,7,8-penta-chlorodibenzofuran (PeCDF) in the Yusho patients has been reported to be approximately seven years. In the present study, we estimated the half-life of PeCDF using data from the medical check-ups of more than 300 Yusho patients. We performed linear regression analysis with a binary logarithm of PeCDF blood level in Yusho patients as the dependent variable, and the measurement year as the independent variable. Our results showed that there were many patients who had shown no reduction of their blood PeCDF level for several years. This result contradicts the previously reported half-life period. Therefore, we believe that a more complicated excretion model needs to be established to explain the discrepancy we found. We hypothesized that there might be two mechanisms of PeCDF assimilation in human digestive tract. In the present study, we also used our hypothesis to simulate PeCDF excretion in Yusho patients.

Original languageEnglish
Pages (from-to)172-178
Number of pages7
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume100
Issue number5
Publication statusPublished - Jan 1 2009
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Akahane, M., Matsumoto, S., Kanagawa, Y., Kajiwara, J., Todaka, T., Hirakawa, H., ... Imamura, T. (2009). Estimated half-life of penta-chlorodibenzofuran (PeCDF) and simulation of PeCDF excretion. Fukuoka igaku zasshi = Hukuoka acta medica, 100(5), 172-178.