Abstract
Morphogenesis is achieved through volumetric growth of tissue at a rate varying over space and time. The volumetric growth rate of each piece of tissue reflects the behaviors of constituent cells such as cell proliferation and death. Hence, clarifying its spatiotemporal pattern accurately is a key to bridge between cell behaviors and organ morphogenesis. We here propose a new method to estimate the spatiotemporal pattern of volumetric growth rate from fate map data with limited resolution on space and time by using a mathematical model. We apply the method to chick wing data along the proximodistal axis, and find that the volumetric growth pattern is biphasic: it is spatially uniform in earlier stages (until stage 23), but in later stages the volumetric growth occurs approximately 4.5 times as fast as in the distal region (within approximately 100 μm from the limb tip) than in the proximal region.
| Original language | English |
|---|---|
| Pages (from-to) | 415-422 |
| Number of pages | 8 |
| Journal | Developmental Dynamics |
| Volume | 238 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2009 |
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All Science Journal Classification (ASJC) codes
- Developmental Biology
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Estimating the spatiotemporal pattern of volumetric growth rate from fate maps in chick limb development. / Morishita, Yoshihiro; Iwasa, Yoh.
In: Developmental Dynamics, Vol. 238, No. 2, 01.02.2009, p. 415-422.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Estimating the spatiotemporal pattern of volumetric growth rate from fate maps in chick limb development
AU - Morishita, Yoshihiro
AU - Iwasa, Yoh
PY - 2009/2/1
Y1 - 2009/2/1
N2 - Morphogenesis is achieved through volumetric growth of tissue at a rate varying over space and time. The volumetric growth rate of each piece of tissue reflects the behaviors of constituent cells such as cell proliferation and death. Hence, clarifying its spatiotemporal pattern accurately is a key to bridge between cell behaviors and organ morphogenesis. We here propose a new method to estimate the spatiotemporal pattern of volumetric growth rate from fate map data with limited resolution on space and time by using a mathematical model. We apply the method to chick wing data along the proximodistal axis, and find that the volumetric growth pattern is biphasic: it is spatially uniform in earlier stages (until stage 23), but in later stages the volumetric growth occurs approximately 4.5 times as fast as in the distal region (within approximately 100 μm from the limb tip) than in the proximal region.
AB - Morphogenesis is achieved through volumetric growth of tissue at a rate varying over space and time. The volumetric growth rate of each piece of tissue reflects the behaviors of constituent cells such as cell proliferation and death. Hence, clarifying its spatiotemporal pattern accurately is a key to bridge between cell behaviors and organ morphogenesis. We here propose a new method to estimate the spatiotemporal pattern of volumetric growth rate from fate map data with limited resolution on space and time by using a mathematical model. We apply the method to chick wing data along the proximodistal axis, and find that the volumetric growth pattern is biphasic: it is spatially uniform in earlier stages (until stage 23), but in later stages the volumetric growth occurs approximately 4.5 times as fast as in the distal region (within approximately 100 μm from the limb tip) than in the proximal region.
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UR - http://www.scopus.com/inward/citedby.url?scp=59649100049&partnerID=8YFLogxK
U2 - 10.1002/dvdy.21840
DO - 10.1002/dvdy.21840
M3 - Article
C2 - 19161240
AN - SCOPUS:59649100049
VL - 238
SP - 415
EP - 422
JO - Developmental Dynamics
JF - Developmental Dynamics
SN - 1058-8388
IS - 2
ER -