Estimation of kinetic parameters in an S-system equation model for a metabolic reaction system using the Newton-Raphson method

Michio Iwata, Kansuporn Sriyudthsak, Masami Yokota Hirai, Fumihide Shiraishi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Metabolic reaction systems can be modeled easily in terms of S-system type equations if their metabolic maps are available. This study therefore proposes a method for estimating parameters in decoupled S-system equations on the basis of the Newton-Raphson method and elucidates the performance of this estimation method. Parameter estimation from the time-course data of metabolite concentrations reveals that the parameters estimated are highly accurate, indicating that the estimation algorithm has been constructed correctly. The number of iterations is small and the calculation converges in a very short time (usually less than 1. s). The method is also applied to time course data with noise and found to estimate parameters efficiently. Results indicate that the present method has the potential to be extended to a method for estimating parameters in large-scale metabolic reaction systems.

Original languageEnglish
Pages (from-to)11-21
Number of pages11
JournalMathematical Biosciences
Volume248
Issue number1
DOIs
Publication statusPublished - Feb 7 2014

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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