Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography

Sitti Fadhillah Oemar Mattalitti, Toshiyuki Kawazu, Shintarou Kawano, Tatsuya Ikari, Hiroko Wada, Kazunori Yoshiura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: To evaluate the feasibility of using ultrasound-obtained tumor depth (TD) and margin shape (MS) to predict the prognosis of tongue cancer. Methods: Fifty-two Japanese patients with tongue cancer who underwent ultrasound examination between 2007 and 2012 were retrospectively evaluated. TD was measured at the deepest portion of the tumor. MS was classified as “pressure,” “wedge-shaped,” or “permeated.” Prognosis was assessed by local recurrence, lymph node metastasis, and overall survival rate. We classified the patients into a good prognosis group and poor prognosis group. Relationships among TD, MS, and patient prognosis were evaluated using Spearman rank correlation. A regression formula to predict prognosis using TD and MS was derived. Results: The correlation between TD and MS was significant (Spearman rank correlation ρ = 0.552, p < 0.01). Using a structure matrix, we identified the contribution of both predictors from an ultrasound image. The contribution of TD was 0.796, while that of MS was better at 0.906. The prognosis could be predicted using the following regression formula: D=-2.801+0.093x+0.872y, where D prognosis (risk probability), x = TD (mm), and y = MS (grade). The average value for good risk probability was −0.254 (standard deviation, 0.962), while that for poor risk probability was 0.566 (standard deviation, 1.08) (p < 0.05). The cut-off value for classifying cases was −0.00169. Using the formula above, 73.1 % of patients in the poor prognosis group were correctly classified. Conclusions: MS and TD are useful predictors of tongue cancer prognosis.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalOral Radiology
Volume33
Issue number2
DOIs
Publication statusPublished - May 1 2017

Fingerprint

Tongue Neoplasms
Ultrasonography
Neoplasms
Pulmonary Wedge Pressure
Survival Rate
Lymph Nodes

All Science Journal Classification (ASJC) codes

  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging

Cite this

Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography. / Mattalitti, Sitti Fadhillah Oemar; Kawazu, Toshiyuki; Kawano, Shintarou; Ikari, Tatsuya; Wada, Hiroko; Yoshiura, Kazunori.

In: Oral Radiology, Vol. 33, No. 2, 01.05.2017, p. 101-107.

Research output: Contribution to journalArticle

Mattalitti, Sitti Fadhillah Oemar ; Kawazu, Toshiyuki ; Kawano, Shintarou ; Ikari, Tatsuya ; Wada, Hiroko ; Yoshiura, Kazunori. / Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography. In: Oral Radiology. 2017 ; Vol. 33, No. 2. pp. 101-107.
@article{632688e902b249859575cc6ce13f8874,
title = "Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography",
abstract = "Objectives: To evaluate the feasibility of using ultrasound-obtained tumor depth (TD) and margin shape (MS) to predict the prognosis of tongue cancer. Methods: Fifty-two Japanese patients with tongue cancer who underwent ultrasound examination between 2007 and 2012 were retrospectively evaluated. TD was measured at the deepest portion of the tumor. MS was classified as “pressure,” “wedge-shaped,” or “permeated.” Prognosis was assessed by local recurrence, lymph node metastasis, and overall survival rate. We classified the patients into a good prognosis group and poor prognosis group. Relationships among TD, MS, and patient prognosis were evaluated using Spearman rank correlation. A regression formula to predict prognosis using TD and MS was derived. Results: The correlation between TD and MS was significant (Spearman rank correlation ρ = 0.552, p < 0.01). Using a structure matrix, we identified the contribution of both predictors from an ultrasound image. The contribution of TD was 0.796, while that of MS was better at 0.906. The prognosis could be predicted using the following regression formula: D=-2.801+0.093x+0.872y, where D prognosis (risk probability), x = TD (mm), and y = MS (grade). The average value for good risk probability was −0.254 (standard deviation, 0.962), while that for poor risk probability was 0.566 (standard deviation, 1.08) (p < 0.05). The cut-off value for classifying cases was −0.00169. Using the formula above, 73.1 {\%} of patients in the poor prognosis group were correctly classified. Conclusions: MS and TD are useful predictors of tongue cancer prognosis.",
author = "Mattalitti, {Sitti Fadhillah Oemar} and Toshiyuki Kawazu and Shintarou Kawano and Tatsuya Ikari and Hiroko Wada and Kazunori Yoshiura",
year = "2017",
month = "5",
day = "1",
doi = "10.1007/s11282-016-0251-y",
language = "English",
volume = "33",
pages = "101--107",
journal = "Oral Radiology",
issn = "0911-6028",
publisher = "Springer Japan",
number = "2",

}

TY - JOUR

T1 - Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography

AU - Mattalitti, Sitti Fadhillah Oemar

AU - Kawazu, Toshiyuki

AU - Kawano, Shintarou

AU - Ikari, Tatsuya

AU - Wada, Hiroko

AU - Yoshiura, Kazunori

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Objectives: To evaluate the feasibility of using ultrasound-obtained tumor depth (TD) and margin shape (MS) to predict the prognosis of tongue cancer. Methods: Fifty-two Japanese patients with tongue cancer who underwent ultrasound examination between 2007 and 2012 were retrospectively evaluated. TD was measured at the deepest portion of the tumor. MS was classified as “pressure,” “wedge-shaped,” or “permeated.” Prognosis was assessed by local recurrence, lymph node metastasis, and overall survival rate. We classified the patients into a good prognosis group and poor prognosis group. Relationships among TD, MS, and patient prognosis were evaluated using Spearman rank correlation. A regression formula to predict prognosis using TD and MS was derived. Results: The correlation between TD and MS was significant (Spearman rank correlation ρ = 0.552, p < 0.01). Using a structure matrix, we identified the contribution of both predictors from an ultrasound image. The contribution of TD was 0.796, while that of MS was better at 0.906. The prognosis could be predicted using the following regression formula: D=-2.801+0.093x+0.872y, where D prognosis (risk probability), x = TD (mm), and y = MS (grade). The average value for good risk probability was −0.254 (standard deviation, 0.962), while that for poor risk probability was 0.566 (standard deviation, 1.08) (p < 0.05). The cut-off value for classifying cases was −0.00169. Using the formula above, 73.1 % of patients in the poor prognosis group were correctly classified. Conclusions: MS and TD are useful predictors of tongue cancer prognosis.

AB - Objectives: To evaluate the feasibility of using ultrasound-obtained tumor depth (TD) and margin shape (MS) to predict the prognosis of tongue cancer. Methods: Fifty-two Japanese patients with tongue cancer who underwent ultrasound examination between 2007 and 2012 were retrospectively evaluated. TD was measured at the deepest portion of the tumor. MS was classified as “pressure,” “wedge-shaped,” or “permeated.” Prognosis was assessed by local recurrence, lymph node metastasis, and overall survival rate. We classified the patients into a good prognosis group and poor prognosis group. Relationships among TD, MS, and patient prognosis were evaluated using Spearman rank correlation. A regression formula to predict prognosis using TD and MS was derived. Results: The correlation between TD and MS was significant (Spearman rank correlation ρ = 0.552, p < 0.01). Using a structure matrix, we identified the contribution of both predictors from an ultrasound image. The contribution of TD was 0.796, while that of MS was better at 0.906. The prognosis could be predicted using the following regression formula: D=-2.801+0.093x+0.872y, where D prognosis (risk probability), x = TD (mm), and y = MS (grade). The average value for good risk probability was −0.254 (standard deviation, 0.962), while that for poor risk probability was 0.566 (standard deviation, 1.08) (p < 0.05). The cut-off value for classifying cases was −0.00169. Using the formula above, 73.1 % of patients in the poor prognosis group were correctly classified. Conclusions: MS and TD are useful predictors of tongue cancer prognosis.

UR - http://www.scopus.com/inward/record.url?scp=84976382049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84976382049&partnerID=8YFLogxK

U2 - 10.1007/s11282-016-0251-y

DO - 10.1007/s11282-016-0251-y

M3 - Article

VL - 33

SP - 101

EP - 107

JO - Oral Radiology

JF - Oral Radiology

SN - 0911-6028

IS - 2

ER -