Estrogen-like activity and prevention effect of bone loss in calcium deficient ovariectomized rats by the extract of Pleurotus eryngii

Kuniyoshi Shimizu, Maiko Yamanaka, Mayumi Gyokusen, Shuhei Kaneko, Mototake Tsutsui, Junichi Sato, Ikuo Sato, Masao Sato, Ryuichiro Kondo

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In the course of a search for natural estrogen-like materials from mushrooms, the proliferating effects of the methanol extracts of 14 edible mushrooms on the estrogen-dependent growth of MCF-7 cells were examined. Of the extracts, that from the fruiting body of Pleurotus eryngii showed the strongest estrogen-like activity, specifically on the proliferating effects of MCF-7 cells. This proliferation effect of the extract from the fruiting body of P. eryngii is related to its estrogenic activity, because this proliferation activity was inhibited by the addition of the antiestrogenic compound ICI 182 780. The ethanol extract of the fruiting body of P. eryngii prevented ovariectomy-induced bone loss. The present data provide evidence that the ethanol extract of P. eryngii helps to protect against the bone loss caused by estrogen deficiency, without having a substantial effect on the uterus.

Original languageEnglish
Pages (from-to)659-664
Number of pages6
JournalPhytotherapy Research
Volume20
Issue number8
DOIs
Publication statusPublished - Aug 1 2006

Fingerprint

Pleurotus
Estrogens
Calcium
Bone and Bones
Agaricales
MCF-7 Cells
Ethanol
Ovariectomy
Uterus
Methanol
Growth

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Estrogen-like activity and prevention effect of bone loss in calcium deficient ovariectomized rats by the extract of Pleurotus eryngii. / Shimizu, Kuniyoshi; Yamanaka, Maiko; Gyokusen, Mayumi; Kaneko, Shuhei; Tsutsui, Mototake; Sato, Junichi; Sato, Ikuo; Sato, Masao; Kondo, Ryuichiro.

In: Phytotherapy Research, Vol. 20, No. 8, 01.08.2006, p. 659-664.

Research output: Contribution to journalArticle

Shimizu, Kuniyoshi ; Yamanaka, Maiko ; Gyokusen, Mayumi ; Kaneko, Shuhei ; Tsutsui, Mototake ; Sato, Junichi ; Sato, Ikuo ; Sato, Masao ; Kondo, Ryuichiro. / Estrogen-like activity and prevention effect of bone loss in calcium deficient ovariectomized rats by the extract of Pleurotus eryngii. In: Phytotherapy Research. 2006 ; Vol. 20, No. 8. pp. 659-664.
@article{fa6c4ac228254444a86a24af7c6ebcb1,
title = "Estrogen-like activity and prevention effect of bone loss in calcium deficient ovariectomized rats by the extract of Pleurotus eryngii",
abstract = "In the course of a search for natural estrogen-like materials from mushrooms, the proliferating effects of the methanol extracts of 14 edible mushrooms on the estrogen-dependent growth of MCF-7 cells were examined. Of the extracts, that from the fruiting body of Pleurotus eryngii showed the strongest estrogen-like activity, specifically on the proliferating effects of MCF-7 cells. This proliferation effect of the extract from the fruiting body of P. eryngii is related to its estrogenic activity, because this proliferation activity was inhibited by the addition of the antiestrogenic compound ICI 182 780. The ethanol extract of the fruiting body of P. eryngii prevented ovariectomy-induced bone loss. The present data provide evidence that the ethanol extract of P. eryngii helps to protect against the bone loss caused by estrogen deficiency, without having a substantial effect on the uterus.",
author = "Kuniyoshi Shimizu and Maiko Yamanaka and Mayumi Gyokusen and Shuhei Kaneko and Mototake Tsutsui and Junichi Sato and Ikuo Sato and Masao Sato and Ryuichiro Kondo",
year = "2006",
month = "8",
day = "1",
doi = "10.1002/ptr.1927",
language = "English",
volume = "20",
pages = "659--664",
journal = "Phytotherapy Research",
issn = "0951-418X",
publisher = "John Wiley and Sons Ltd",
number = "8",

}

TY - JOUR

T1 - Estrogen-like activity and prevention effect of bone loss in calcium deficient ovariectomized rats by the extract of Pleurotus eryngii

AU - Shimizu, Kuniyoshi

AU - Yamanaka, Maiko

AU - Gyokusen, Mayumi

AU - Kaneko, Shuhei

AU - Tsutsui, Mototake

AU - Sato, Junichi

AU - Sato, Ikuo

AU - Sato, Masao

AU - Kondo, Ryuichiro

PY - 2006/8/1

Y1 - 2006/8/1

N2 - In the course of a search for natural estrogen-like materials from mushrooms, the proliferating effects of the methanol extracts of 14 edible mushrooms on the estrogen-dependent growth of MCF-7 cells were examined. Of the extracts, that from the fruiting body of Pleurotus eryngii showed the strongest estrogen-like activity, specifically on the proliferating effects of MCF-7 cells. This proliferation effect of the extract from the fruiting body of P. eryngii is related to its estrogenic activity, because this proliferation activity was inhibited by the addition of the antiestrogenic compound ICI 182 780. The ethanol extract of the fruiting body of P. eryngii prevented ovariectomy-induced bone loss. The present data provide evidence that the ethanol extract of P. eryngii helps to protect against the bone loss caused by estrogen deficiency, without having a substantial effect on the uterus.

AB - In the course of a search for natural estrogen-like materials from mushrooms, the proliferating effects of the methanol extracts of 14 edible mushrooms on the estrogen-dependent growth of MCF-7 cells were examined. Of the extracts, that from the fruiting body of Pleurotus eryngii showed the strongest estrogen-like activity, specifically on the proliferating effects of MCF-7 cells. This proliferation effect of the extract from the fruiting body of P. eryngii is related to its estrogenic activity, because this proliferation activity was inhibited by the addition of the antiestrogenic compound ICI 182 780. The ethanol extract of the fruiting body of P. eryngii prevented ovariectomy-induced bone loss. The present data provide evidence that the ethanol extract of P. eryngii helps to protect against the bone loss caused by estrogen deficiency, without having a substantial effect on the uterus.

UR - http://www.scopus.com/inward/record.url?scp=33747227454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747227454&partnerID=8YFLogxK

U2 - 10.1002/ptr.1927

DO - 10.1002/ptr.1927

M3 - Article

VL - 20

SP - 659

EP - 664

JO - Phytotherapy Research

JF - Phytotherapy Research

SN - 0951-418X

IS - 8

ER -