Estrogen nhances malignant phenotypes in human salivary adenoid cystic carcinoma cells

Tomoki Sumida; Akiko Ishikawa; Yu Kamata; Hiroyuki Nakano; Tomohiro Yamada; Yoshihide Mori

Estrogen nhances malignant phenotypes in human salivary adenoid cystic carcinoma cells

Tomoki Sumida, Akiko Ishikawa, Yu Kamata, Hiroyuki Nakano, Tomohiro Yamada, Yoshihide Mori

Research output: Contribution to journal › Article › peer-review

Abstract

Background/Aim: Adenoid cystic carcinoma (SGC) is a common type of salivary gland cancer (SGC). Surgery is the first treatment choice because chemoradiotherapy is usually not effective. Therefore, new treatment modalities are urgently needed. In this study, it was investigated whether the estrogen axis could be a treatment target or not. Materials and Methods: Adenoid cystic carcinoma (ACC) ACCM cells, were used. The specific cell line lacks estrogen receptor (ER). ER was introduced in ACCM cells, and the effect of 17estradiol (E2) was investigated on cell proliferation, cell-cycle distribution, and cell motility. Results: E2 induced cell proliferation, and the S-phase fraction increased in a dose-dependent manner. Cell motility was also up-regulated compared to control cells. Conclusion: The estrogen/ER system up-regulated malignant phenotypes in ER-positive ACC, and hormone therapy may have a potential as effective treatment for this malignancy.

Original language	English
Pages (from-to)	2793-2798
Number of pages	6
Journal	Anticancer research
Volume	36
Issue number	6
Publication status	Published - Jun 2016

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Estrogen nhances malignant phenotypes in human salivary adenoid cystic carcinoma cells",

abstract = "Background/Aim: Adenoid cystic carcinoma (SGC) is a common type of salivary gland cancer (SGC). Surgery is the first treatment choice because chemoradiotherapy is usually not effective. Therefore, new treatment modalities are urgently needed. In this study, it was investigated whether the estrogen axis could be a treatment target or not. Materials and Methods: Adenoid cystic carcinoma (ACC) ACCM cells, were used. The specific cell line lacks estrogen receptor (ER). ER was introduced in ACCM cells, and the effect of 17estradiol (E2) was investigated on cell proliferation, cell-cycle distribution, and cell motility. Results: E2 induced cell proliferation, and the S-phase fraction increased in a dose-dependent manner. Cell motility was also up-regulated compared to control cells. Conclusion: The estrogen/ER system up-regulated malignant phenotypes in ER-positive ACC, and hormone therapy may have a potential as effective treatment for this malignancy.",

author = "Tomoki Sumida and Akiko Ishikawa and Yu Kamata and Hiroyuki Nakano and Tomohiro Yamada and Yoshihide Mori",

year = "2016",

month = jun,

language = "English",

volume = "36",

pages = "2793--2798",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "6",

}

TY - JOUR

T1 - Estrogen nhances malignant phenotypes in human salivary adenoid cystic carcinoma cells

AU - Sumida, Tomoki

AU - Ishikawa, Akiko

AU - Kamata, Yu

AU - Nakano, Hiroyuki

AU - Yamada, Tomohiro

AU - Mori, Yoshihide

PY - 2016/6

Y1 - 2016/6

N2 - Background/Aim: Adenoid cystic carcinoma (SGC) is a common type of salivary gland cancer (SGC). Surgery is the first treatment choice because chemoradiotherapy is usually not effective. Therefore, new treatment modalities are urgently needed. In this study, it was investigated whether the estrogen axis could be a treatment target or not. Materials and Methods: Adenoid cystic carcinoma (ACC) ACCM cells, were used. The specific cell line lacks estrogen receptor (ER). ER was introduced in ACCM cells, and the effect of 17estradiol (E2) was investigated on cell proliferation, cell-cycle distribution, and cell motility. Results: E2 induced cell proliferation, and the S-phase fraction increased in a dose-dependent manner. Cell motility was also up-regulated compared to control cells. Conclusion: The estrogen/ER system up-regulated malignant phenotypes in ER-positive ACC, and hormone therapy may have a potential as effective treatment for this malignancy.

AB - Background/Aim: Adenoid cystic carcinoma (SGC) is a common type of salivary gland cancer (SGC). Surgery is the first treatment choice because chemoradiotherapy is usually not effective. Therefore, new treatment modalities are urgently needed. In this study, it was investigated whether the estrogen axis could be a treatment target or not. Materials and Methods: Adenoid cystic carcinoma (ACC) ACCM cells, were used. The specific cell line lacks estrogen receptor (ER). ER was introduced in ACCM cells, and the effect of 17estradiol (E2) was investigated on cell proliferation, cell-cycle distribution, and cell motility. Results: E2 induced cell proliferation, and the S-phase fraction increased in a dose-dependent manner. Cell motility was also up-regulated compared to control cells. Conclusion: The estrogen/ER system up-regulated malignant phenotypes in ER-positive ACC, and hormone therapy may have a potential as effective treatment for this malignancy.

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M3 - Article

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AN - SCOPUS:84991583780

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JO - Anticancer Research

JF - Anticancer Research

IS - 6

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Estrogen nhances malignant phenotypes in human salivary adenoid cystic carcinoma cells

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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