Estrogen-receptor-negative breast cancer tissue is chemosensitive in vitro compared with estrogen-receptor-positive tissue

Yoshihiko Maehara, Y. Emi, Y. Sakaguchi, T. Kusumoto, Y. Kakeji, S. Kohnoe, K. Sugimachi

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The chemosensitivities of 18 estrogen–receptor–positive (ER+) tissues were compared with that of 38 estrogen–receptor–negative (ER–) tissues, using the in vitro succinate dehydrogenase inhibition test. These human breast tissues were exposed to six antitumor drugs: carboquone, adriamycin, mitomycin C, aclacinomycin A, cisplatin and 5–fluorouracil. Decrease in succinate dehydrogenase activity was noted in ER" compared to ER+ tissues, exposed to six antitumor drugs, in particular to adriamycin (p < 0.001) and aclacinomycin A (p < 0.05). The sensitive rates were higher in ER" than in ER+ tissues, against all six antitumor drugs. The resistance rates to all drugs tested were 25% in ER" and 45% in ER+ tissues. A higher chemosensitivity is associated with the absence of ER. It appeared that the ER status in case of breast cancer is an important predictor of the response to chemotherapy.

Original languageEnglish
Pages (from-to)50-56
Number of pages7
JournalEuropean Surgical Research
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 1990

All Science Journal Classification (ASJC) codes

  • Surgery

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