Estrous-cycle-dependent variation in orthodontic tooth movement

Naoto Haruyama, K. Igarashi, S. Saeki, M. Otsuka-Isoya, H. Shinoda, H. Mitani

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Sex hormones, including estradiol, play important physiological roles in bone metabolism. The purpose of this study was to investigate whether there is estrous-cycle-dependent variation in orthodontic tooth movement, and, if so, to determine the mechanism. Ten-week-old female Wistar rats were used. They received repeated orthodontic force during specific phases in the estrous cycle. Tooth movement in animals that received force principally in estrus was about 33% greater than that in animals that received such force principally in pro-estrus (p < 0.05). Serum estradiol levels also varied according to the estrous cycle, with a peak during pro-estrus and a nadir during estrus, and were inversely related to tooth movement. Furthermore, there were negative correlations between estradiol and both serum TRAP activity and pyridinoline (r = -0.42, p < 0.05; r = 0.59, p < 0.001). These results suggest that cyclic changes in the estradiol level may be associated with the estrous-cycle-dependent variation in tooth movement through its effects on bone resorption.

Original languageEnglish
Pages (from-to)406-410
Number of pages5
JournalJournal of Dental Research
Volume81
Issue number6
DOIs
Publication statusPublished - Jan 1 2002
Externally publishedYes

Fingerprint

Tooth Movement Techniques
Estrous Cycle
Estrus
Estradiol
Gonadal Steroid Hormones
Bone Resorption
Orthodontics
Serum
Wistar Rats
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Haruyama, N., Igarashi, K., Saeki, S., Otsuka-Isoya, M., Shinoda, H., & Mitani, H. (2002). Estrous-cycle-dependent variation in orthodontic tooth movement. Journal of Dental Research, 81(6), 406-410. https://doi.org/10.1177/154405910208100610

Estrous-cycle-dependent variation in orthodontic tooth movement. / Haruyama, Naoto; Igarashi, K.; Saeki, S.; Otsuka-Isoya, M.; Shinoda, H.; Mitani, H.

In: Journal of Dental Research, Vol. 81, No. 6, 01.01.2002, p. 406-410.

Research output: Contribution to journalArticle

Haruyama, N, Igarashi, K, Saeki, S, Otsuka-Isoya, M, Shinoda, H & Mitani, H 2002, 'Estrous-cycle-dependent variation in orthodontic tooth movement', Journal of Dental Research, vol. 81, no. 6, pp. 406-410. https://doi.org/10.1177/154405910208100610
Haruyama, Naoto ; Igarashi, K. ; Saeki, S. ; Otsuka-Isoya, M. ; Shinoda, H. ; Mitani, H. / Estrous-cycle-dependent variation in orthodontic tooth movement. In: Journal of Dental Research. 2002 ; Vol. 81, No. 6. pp. 406-410.
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