Ethyl 4-[(1-substituted indol-2-yl)methoxy]benzoates and indoline derivatives: Anti-juvenile hormone and juvenile hormone activities

Kenjiro Furuta, Shuhei Yoshida, Norihiro Fujita, Naotaka Yamada, Eiichi Kuwano

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A number of ethyl 4-[(1-substituted indol-2-yl)methoxy]benzoates and indoline derivatives were prepared as rigid congeners of ethyl 4-(2-benzylhexyloxy)benzoate (KF-13), an anti-juvenile hormone (anti-JH) agent, and tested for both anti-JH and JH activities in silkworm larvae. In contrast to KF-13, the precocious metamorphosis-inducing activity of which decreased by increasing the applied doses, 1-n-propyl, 1-n-butyl (1c) and 1-benzyl (1d) derivatives were found to induce higher percentages of precocious metamorphosis at high doses. Compounds 1c and 1d also exhibited JH activity when topically applied to allatectomized 4th instar larvae. Ethyl 4-[(S)-(1-n-butylindolin-2-yl)methoxy]benzoate, which showed precocious metamorphosis-inducing activity at high doses, had no JH activity.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalJournal of Pesticide Science
Issue number3
Publication statusPublished - Dec 1 2009


All Science Journal Classification (ASJC) codes

  • Insect Science
  • Health, Toxicology and Mutagenesis

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