Evaluating glycogen signal contamination in muscle by 13C MRS of the liver

Moyoko Tomiyasu, Takayuki Obata, Hiroi Nonaka, Yukio Nishi, Hiromitsu Nakamoto, Yukihisa Takayama, Hiroo Ikehira, Iwao Kanno

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Abstract

To evaluate the contamination of glycogen signal synthesized in skeletal muscle by that in the liver, long-term monitoring of over 7 h of in vivo [1-13C] glycogen synthesis/degradation at the right abdomen and left shoulder was achieved using a 3.0-T clinical MR system. 13C MR spectra without localization were obtained from five healthy volunteers before and after oral administration of 85 g of d-glucose, including 10 g of 99% [1-13C] glucose. In all volunteers, the relative signal intensities at the abdomen to those at shoulder were about two- to fivefold, and those of time-course changes at the abdomen and shoulder were dissimilar. It is considered that the quantity of muscle-synthesized glycogen signal at the abdomen is less than that at the shoulder because of the lesser muscle volume at the abdomen, and it may be less affected for evaluating glycogen synthesis/degradation in the liver even without localization pulses.

Original languageEnglish
Pages (from-to)572-576
Number of pages5
JournalMagnetic Resonance Imaging
Volume26
Issue number4
DOIs
Publication statusPublished - May 1 2008

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Tomiyasu, M., Obata, T., Nonaka, H., Nishi, Y., Nakamoto, H., Takayama, Y., ... Kanno, I. (2008). Evaluating glycogen signal contamination in muscle by 13C MRS of the liver. Magnetic Resonance Imaging, 26(4), 572-576. https://doi.org/10.1016/j.mri.2007.09.002