Evaluating the effectiveness of a single CT method for attenuation correction in stress-rest myocardial perfusion imaging with thallium-201 chloride SPECT

Mitsuha Fukami, Kiyoshi Tamura, Yuya Nakamura, Syoichi Nakatsukasa, Masayuki Sasaki

Research output: Contribution to journalArticle

Abstract

This study aimed to evaluate the effectiveness of a single computed tomography (CT) based attenuation correction method using thallium-201 chloride (201TlCl) in stress-rest myocardial perfusion imaging (MPI). The data of 106 patients who underwent MPI with single photon emission computed tomography (SPECT) using 201TlCl were retrospectively reviewed. MPI SPECT images were reconstructed using stress SPECT and stress CT (SIO), rest SPECT and rest CT (RIO), and rest SPECT and stress CT (RIA). The accuracy of alignment between the SPECT and CT images was evaluated with normalized cross-correlation (NCC) and visual examination. The summed rest score (SRS) was used to evaluate hypoperfusion at rest; washout rate (WO) was used to assess ischemia; and left ventricular ejection fraction (LVEF) was used to evaluate the left ventricle (LV) function. There was no significant difference in NCC and visual evaluation in all three dimensions. The SRS of both RIO and RIA (7.5 ± 7.7 and 7.7 ± 7.6, respectively) did not differ significantly. However, SRSs of RIO and RIA showed a strong correlation (r = 0.98). The WO was 39.0 ± 0.98% for both RIO and RIA, with a strong correlation between the two values (r = 1.00). LVEF was 61.1 ± 17.4% for RIO and 61.3 ± 17.4% for RIA, and a strong correlation was observed between the two values (r = 1.00). In conclusion, the single CT-based attenuation correction method with 201TlCl SPECT has an accuracy equivalent to that of the conventional two CT-based attenuation correction method.

Original languageEnglish
JournalRadiological physics and technology
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Myocardial Perfusion Imaging
thallium
Single-Photon Emission-Computed Tomography
tomography
attenuation
chlorides
Tomography
photons
Stroke Volume
Heart Ventricles
Ischemia
fallout
Single Photon Emission Computed Tomography Computed Tomography
thallium chloride
ejection
cross correlation
ischemia

All Science Journal Classification (ASJC) codes

  • Radiation
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Radiology Nuclear Medicine and imaging

Cite this

Evaluating the effectiveness of a single CT method for attenuation correction in stress-rest myocardial perfusion imaging with thallium-201 chloride SPECT. / Fukami, Mitsuha; Tamura, Kiyoshi; Nakamura, Yuya; Nakatsukasa, Syoichi; Sasaki, Masayuki.

In: Radiological physics and technology, 01.01.2019.

Research output: Contribution to journalArticle

@article{dfffac5b8c02465aa0b5a1ef192ccb3d,
title = "Evaluating the effectiveness of a single CT method for attenuation correction in stress-rest myocardial perfusion imaging with thallium-201 chloride SPECT",
abstract = "This study aimed to evaluate the effectiveness of a single computed tomography (CT) based attenuation correction method using thallium-201 chloride (201TlCl) in stress-rest myocardial perfusion imaging (MPI). The data of 106 patients who underwent MPI with single photon emission computed tomography (SPECT) using 201TlCl were retrospectively reviewed. MPI SPECT images were reconstructed using stress SPECT and stress CT (SIO), rest SPECT and rest CT (RIO), and rest SPECT and stress CT (RIA). The accuracy of alignment between the SPECT and CT images was evaluated with normalized cross-correlation (NCC) and visual examination. The summed rest score (SRS) was used to evaluate hypoperfusion at rest; washout rate (WO) was used to assess ischemia; and left ventricular ejection fraction (LVEF) was used to evaluate the left ventricle (LV) function. There was no significant difference in NCC and visual evaluation in all three dimensions. The SRS of both RIO and RIA (7.5 ± 7.7 and 7.7 ± 7.6, respectively) did not differ significantly. However, SRSs of RIO and RIA showed a strong correlation (r = 0.98). The WO was 39.0 ± 0.98{\%} for both RIO and RIA, with a strong correlation between the two values (r = 1.00). LVEF was 61.1 ± 17.4{\%} for RIO and 61.3 ± 17.4{\%} for RIA, and a strong correlation was observed between the two values (r = 1.00). In conclusion, the single CT-based attenuation correction method with 201TlCl SPECT has an accuracy equivalent to that of the conventional two CT-based attenuation correction method.",
author = "Mitsuha Fukami and Kiyoshi Tamura and Yuya Nakamura and Syoichi Nakatsukasa and Masayuki Sasaki",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s12194-019-00540-8",
language = "English",
journal = "Radiological Physics and Technology",
issn = "1865-0333",
publisher = "Springer Japan",

}

TY - JOUR

T1 - Evaluating the effectiveness of a single CT method for attenuation correction in stress-rest myocardial perfusion imaging with thallium-201 chloride SPECT

AU - Fukami, Mitsuha

AU - Tamura, Kiyoshi

AU - Nakamura, Yuya

AU - Nakatsukasa, Syoichi

AU - Sasaki, Masayuki

PY - 2019/1/1

Y1 - 2019/1/1

N2 - This study aimed to evaluate the effectiveness of a single computed tomography (CT) based attenuation correction method using thallium-201 chloride (201TlCl) in stress-rest myocardial perfusion imaging (MPI). The data of 106 patients who underwent MPI with single photon emission computed tomography (SPECT) using 201TlCl were retrospectively reviewed. MPI SPECT images were reconstructed using stress SPECT and stress CT (SIO), rest SPECT and rest CT (RIO), and rest SPECT and stress CT (RIA). The accuracy of alignment between the SPECT and CT images was evaluated with normalized cross-correlation (NCC) and visual examination. The summed rest score (SRS) was used to evaluate hypoperfusion at rest; washout rate (WO) was used to assess ischemia; and left ventricular ejection fraction (LVEF) was used to evaluate the left ventricle (LV) function. There was no significant difference in NCC and visual evaluation in all three dimensions. The SRS of both RIO and RIA (7.5 ± 7.7 and 7.7 ± 7.6, respectively) did not differ significantly. However, SRSs of RIO and RIA showed a strong correlation (r = 0.98). The WO was 39.0 ± 0.98% for both RIO and RIA, with a strong correlation between the two values (r = 1.00). LVEF was 61.1 ± 17.4% for RIO and 61.3 ± 17.4% for RIA, and a strong correlation was observed between the two values (r = 1.00). In conclusion, the single CT-based attenuation correction method with 201TlCl SPECT has an accuracy equivalent to that of the conventional two CT-based attenuation correction method.

AB - This study aimed to evaluate the effectiveness of a single computed tomography (CT) based attenuation correction method using thallium-201 chloride (201TlCl) in stress-rest myocardial perfusion imaging (MPI). The data of 106 patients who underwent MPI with single photon emission computed tomography (SPECT) using 201TlCl were retrospectively reviewed. MPI SPECT images were reconstructed using stress SPECT and stress CT (SIO), rest SPECT and rest CT (RIO), and rest SPECT and stress CT (RIA). The accuracy of alignment between the SPECT and CT images was evaluated with normalized cross-correlation (NCC) and visual examination. The summed rest score (SRS) was used to evaluate hypoperfusion at rest; washout rate (WO) was used to assess ischemia; and left ventricular ejection fraction (LVEF) was used to evaluate the left ventricle (LV) function. There was no significant difference in NCC and visual evaluation in all three dimensions. The SRS of both RIO and RIA (7.5 ± 7.7 and 7.7 ± 7.6, respectively) did not differ significantly. However, SRSs of RIO and RIA showed a strong correlation (r = 0.98). The WO was 39.0 ± 0.98% for both RIO and RIA, with a strong correlation between the two values (r = 1.00). LVEF was 61.1 ± 17.4% for RIO and 61.3 ± 17.4% for RIA, and a strong correlation was observed between the two values (r = 1.00). In conclusion, the single CT-based attenuation correction method with 201TlCl SPECT has an accuracy equivalent to that of the conventional two CT-based attenuation correction method.

UR - http://www.scopus.com/inward/record.url?scp=85075954397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075954397&partnerID=8YFLogxK

U2 - 10.1007/s12194-019-00540-8

DO - 10.1007/s12194-019-00540-8

M3 - Article

C2 - 31768935

AN - SCOPUS:85075954397

JO - Radiological Physics and Technology

JF - Radiological Physics and Technology

SN - 1865-0333

ER -