Evaluation for cellular specificity of comb-type copolymer having hyaluronic acid side chains

Naohisa Fujii, Sung Won Choi, Arihiro Kano, Toshihiro Akaike, Atsushi Maruyama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nucleic acid medicines (e.g. RNAi, antisense etc.) have increasingly become a powerful tool for genetic analysis and are likely to become a potent therapeutic approach for intractable diseases. However, the major obstacle to use them as therapeutics is the difficulty of in vivo delivery. Though cationic comb-type polymer having HA side chains has used for site-specific delivery of plasmid DNA into liver sinusoidal endothelial cells (LSEC) effectively, it has less binding ability to short nucleic acid such as siRNAs and antisense DNA. Therefore we introduced guanidino moieties into PLL main chains to enhance the binding affinity.

Original languageEnglish
Title of host publication54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan
Pages2147
Number of pages1
Volume54
Edition1
Publication statusPublished - 2005
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: May 25 2005May 27 2005

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period5/25/055/27/05

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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  • Cite this

    Fujii, N., Choi, S. W., Kano, A., Akaike, T., & Maruyama, A. (2005). Evaluation for cellular specificity of comb-type copolymer having hyaluronic acid side chains. In 54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan (1 ed., Vol. 54, pp. 2147)