Evaluation of brain redox status and its association with cognitive dysfunction in diabetic animal models by redox molecular imaging (ReMI)

Noriyuki Sonoda; Toyoshi Inoguchi; Yohei Minami; Fuminori Hyodo; Kazuhiro Ichikawa; Mayumi Yamato; Hideo Utsumi; Ryoichi Takayanagi

doi:10.1248/yakushi.15-00234-2

Evaluation of brain redox status and its association with cognitive dysfunction in diabetic animal models by redox molecular imaging (ReMI)

Noriyuki Sonoda, Toyoshi Inoguchi, Yohei Minami, Fuminori Hyodo, Kazuhiro Ichikawa, Mayumi Yamato, Hideo Utsumi, Ryoichi Takayanagi

Department of Endocrine and Metabolic Diseases / Diabetes Mellitus

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Oxidative stress contributes to the development of diabetic complications. Increasing epidemiologic evidence suggests that diabetes mellitus is associated with dementia and cognitive decline. However, the underlying mechanisms are not fully understood. We have evaluated brain redox status and its association of cognitive dysfunction in diabetic animal models by dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) and other oxidative stress markers. In this review, we discuss the role of oxidative stress in the development of diabetes-related dementia and clinical regulation of the redox state in new approaches to augmenting diabetes-related dementia.

Original language	English
Pages (from-to)	1081-1086
Number of pages	6
Journal	Yakugaku Zasshi
Volume	136
Issue number	8
DOIs	https://doi.org/10.1248/yakushi.15-00234-2
Publication status	Published - 2016

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science

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10.1248/yakushi.15-00234-2

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abstract = "Oxidative stress contributes to the development of diabetic complications. Increasing epidemiologic evidence suggests that diabetes mellitus is associated with dementia and cognitive decline. However, the underlying mechanisms are not fully understood. We have evaluated brain redox status and its association of cognitive dysfunction in diabetic animal models by dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) and other oxidative stress markers. In this review, we discuss the role of oxidative stress in the development of diabetes-related dementia and clinical regulation of the redox state in new approaches to augmenting diabetes-related dementia.",

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T1 - Evaluation of brain redox status and its association with cognitive dysfunction in diabetic animal models by redox molecular imaging (ReMI)

AU - Sonoda, Noriyuki

AU - Inoguchi, Toyoshi

AU - Minami, Yohei

AU - Hyodo, Fuminori

AU - Ichikawa, Kazuhiro

AU - Yamato, Mayumi

AU - Utsumi, Hideo

AU - Takayanagi, Ryoichi

PY - 2016

Y1 - 2016

N2 - Oxidative stress contributes to the development of diabetic complications. Increasing epidemiologic evidence suggests that diabetes mellitus is associated with dementia and cognitive decline. However, the underlying mechanisms are not fully understood. We have evaluated brain redox status and its association of cognitive dysfunction in diabetic animal models by dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) and other oxidative stress markers. In this review, we discuss the role of oxidative stress in the development of diabetes-related dementia and clinical regulation of the redox state in new approaches to augmenting diabetes-related dementia.

AB - Oxidative stress contributes to the development of diabetic complications. Increasing epidemiologic evidence suggests that diabetes mellitus is associated with dementia and cognitive decline. However, the underlying mechanisms are not fully understood. We have evaluated brain redox status and its association of cognitive dysfunction in diabetic animal models by dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) and other oxidative stress markers. In this review, we discuss the role of oxidative stress in the development of diabetes-related dementia and clinical regulation of the redox state in new approaches to augmenting diabetes-related dementia.

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Evaluation of brain redox status and its association with cognitive dysfunction in diabetic animal models by redox molecular imaging (ReMI)

Abstract

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