Evaluation of brain redox status and its association with cognitive dysfunction in diabetic animal models by redox molecular imaging (ReMI)

Noriyuki Sonoda, Toyoshi Inoguchi, Yohei Minami, Fuminori Hyodo, Kazuhiro Ichikawa, Mayumi Yamato, Hideo Utsumi, Ryoichi Takayanagi

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Oxidative stress contributes to the development of diabetic complications. Increasing epidemiologic evidence suggests that diabetes mellitus is associated with dementia and cognitive decline. However, the underlying mechanisms are not fully understood. We have evaluated brain redox status and its association of cognitive dysfunction in diabetic animal models by dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) and other oxidative stress markers. In this review, we discuss the role of oxidative stress in the development of diabetes-related dementia and clinical regulation of the redox state in new approaches to augmenting diabetes-related dementia.

Original languageEnglish
Pages (from-to)1081-1086
Number of pages6
JournalYakugaku Zasshi
Volume136
Issue number8
DOIs
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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