Evaluation of cardiac oxygen consumption under hypoxia with tissue model integrating microcirculation model and cell model

Akira Amano, Yuuta Kubota, Takao Shimayoshi, Tetsuya Matsuda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Analyzing the microscopic energy balance of cardiac tissue is very important for understanding heart diseases. However, such analysis is difficult with animal experiments. Therefore, the accurate simulation model is expected to be an important tool for such research. We propose a cardiac tissue model which can reproduce accurate distribution of oxygen consumption under hypoxia. The model includes blood tissue exchange model of capillary and oxygen consumption model of cells. The capillary model is based on the model proposed by Dash et al. 2006, and the cell model is based on the model proposed by Kuzumoto et al. 2007. By analyzing the oxygen consumption of the proposed model, the relation between the oxygen consumption and the arterial oxygen concentration was found to be largely different from that of single cell model. This implies that the animal experimental data should be carefully used for constructing a biological simulation model, depending on whether the experiment is performed within a cell or a tissue.

Original languageEnglish
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC 2009
PublisherIEEE Computer Society
Pages3885-3888
Number of pages4
ISBN (Print)9781424432967
DOIs
Publication statusPublished - Jan 1 2009
Externally publishedYes
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

Fingerprint

Microcirculation
Oxygen Consumption
Tissue
Oxygen
Biological Models
Heart Diseases
Hypoxia
Animals
Research
Energy balance

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Amano, A., Kubota, Y., Shimayoshi, T., & Matsuda, T. (2009). Evaluation of cardiac oxygen consumption under hypoxia with tissue model integrating microcirculation model and cell model. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 3885-3888). [5332645] IEEE Computer Society. https://doi.org/10.1109/IEMBS.2009.5332645

Evaluation of cardiac oxygen consumption under hypoxia with tissue model integrating microcirculation model and cell model. / Amano, Akira; Kubota, Yuuta; Shimayoshi, Takao; Matsuda, Tetsuya.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. p. 3885-3888 5332645.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Amano, A, Kubota, Y, Shimayoshi, T & Matsuda, T 2009, Evaluation of cardiac oxygen consumption under hypoxia with tissue model integrating microcirculation model and cell model. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5332645, IEEE Computer Society, pp. 3885-3888, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5332645
Amano A, Kubota Y, Shimayoshi T, Matsuda T. Evaluation of cardiac oxygen consumption under hypoxia with tissue model integrating microcirculation model and cell model. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society. 2009. p. 3885-3888. 5332645 https://doi.org/10.1109/IEMBS.2009.5332645
Amano, Akira ; Kubota, Yuuta ; Shimayoshi, Takao ; Matsuda, Tetsuya. / Evaluation of cardiac oxygen consumption under hypoxia with tissue model integrating microcirculation model and cell model. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. pp. 3885-3888
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