Evaluation of carotid artery outward remodeling by T1-weighted magnetic resonance imaging in carotid endarterectomy and stenting

Daisuke Maruyama, Kenji Fukuda, Hiroharu Kataoka, Yoshiaki Morita, Kunihiro Nishimura, Yoichiro Kawamura, Koji Iihara

Research output: Contribution to journalArticle

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Abstract

Objective We evaluated carotid artery outward remodeling and plaque relative signal intensity (rSI) using T1-weighted magnetic resonance imaging (T1-MRI) to investigate their clinical significance in carotid revascularization. Methods From 86 patients undergoing carotid endarterectomy (CEA) or carotid artery stenting (CAS), 88 lesions (51 lesions treated with CEA and 37 lesions treated with CAS) were analyzed retrospectively. We evaluated the preoperative carotid artery remodeling index (CRI), determined by a ratio of the external cross-sectional vessel area at maximum stenosis and the reference cross-sectional vessel area at the distal portion of the internal carotid artery, and the plaque rSI, which is quantified as the ratio between the signal intensities of plaque and adjacent muscle using T1-MRI. We divided carotid lesions into four groups using the median values of CRI and rSI: L/L (CRI < 1.8, rSI < 2.5), H/L (CRI ≥ 1.8, rSI < 2.5), L/H (CRI < 1.8, rSI ≥ 2.5), and H/H (CRI ≥ 1.8, rSI ≥ 2.5). The primary end point was detection of acute ipsilateral ischemia on diffusion-weighted imaging (DWI) within 72 hours of treatment. Results Mean CRI and rSI were significantly higher in lesions treated with CEA than in those treated with CAS. Postoperative DWI abnormalities were observed in 4 CEA cases (7.8%) and 10 CAS cases (27.0%) (P =.01). In the CAS group, the frequency of DWI abnormalities was 5.5% for the L/L, 40.0% for the H/L and L/H, and 55.5% for the H/H group (P =.009). Multivariate analysis showed that the degree of stenosis and H/H lesion were independent risk factors for cerebral embolism. No correlation was found between plaque parameters and postoperative DWI findings in the CEA group. Conclusions CRI and rSI provide complementary information for the prediction of high-risk plaques associated with CAS but not with CEA. Preoperative evaluation with T1-MRI facilitates the selection of a treatment strategy for carotid artery stenosis.

Original languageEnglish
Pages (from-to)1464-1471.e1
JournalJournal of Vascular Surgery
Volume61
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

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Carotid Endarterectomy
Carotid Arteries
Magnetic Resonance Imaging
Carotid Stenosis
Pathologic Constriction
Intracranial Embolism
Internal Carotid Artery

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine

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Evaluation of carotid artery outward remodeling by T1-weighted magnetic resonance imaging in carotid endarterectomy and stenting. / Maruyama, Daisuke; Fukuda, Kenji; Kataoka, Hiroharu; Morita, Yoshiaki; Nishimura, Kunihiro; Kawamura, Yoichiro; Iihara, Koji.

In: Journal of Vascular Surgery, Vol. 61, No. 6, 01.06.2015, p. 1464-1471.e1.

Research output: Contribution to journalArticle

Maruyama, Daisuke ; Fukuda, Kenji ; Kataoka, Hiroharu ; Morita, Yoshiaki ; Nishimura, Kunihiro ; Kawamura, Yoichiro ; Iihara, Koji. / Evaluation of carotid artery outward remodeling by T1-weighted magnetic resonance imaging in carotid endarterectomy and stenting. In: Journal of Vascular Surgery. 2015 ; Vol. 61, No. 6. pp. 1464-1471.e1.
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abstract = "Objective We evaluated carotid artery outward remodeling and plaque relative signal intensity (rSI) using T1-weighted magnetic resonance imaging (T1-MRI) to investigate their clinical significance in carotid revascularization. Methods From 86 patients undergoing carotid endarterectomy (CEA) or carotid artery stenting (CAS), 88 lesions (51 lesions treated with CEA and 37 lesions treated with CAS) were analyzed retrospectively. We evaluated the preoperative carotid artery remodeling index (CRI), determined by a ratio of the external cross-sectional vessel area at maximum stenosis and the reference cross-sectional vessel area at the distal portion of the internal carotid artery, and the plaque rSI, which is quantified as the ratio between the signal intensities of plaque and adjacent muscle using T1-MRI. We divided carotid lesions into four groups using the median values of CRI and rSI: L/L (CRI < 1.8, rSI < 2.5), H/L (CRI ≥ 1.8, rSI < 2.5), L/H (CRI < 1.8, rSI ≥ 2.5), and H/H (CRI ≥ 1.8, rSI ≥ 2.5). The primary end point was detection of acute ipsilateral ischemia on diffusion-weighted imaging (DWI) within 72 hours of treatment. Results Mean CRI and rSI were significantly higher in lesions treated with CEA than in those treated with CAS. Postoperative DWI abnormalities were observed in 4 CEA cases (7.8{\%}) and 10 CAS cases (27.0{\%}) (P =.01). In the CAS group, the frequency of DWI abnormalities was 5.5{\%} for the L/L, 40.0{\%} for the H/L and L/H, and 55.5{\%} for the H/H group (P =.009). Multivariate analysis showed that the degree of stenosis and H/H lesion were independent risk factors for cerebral embolism. No correlation was found between plaque parameters and postoperative DWI findings in the CEA group. Conclusions CRI and rSI provide complementary information for the prediction of high-risk plaques associated with CAS but not with CEA. Preoperative evaluation with T1-MRI facilitates the selection of a treatment strategy for carotid artery stenosis.",
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T1 - Evaluation of carotid artery outward remodeling by T1-weighted magnetic resonance imaging in carotid endarterectomy and stenting

AU - Maruyama, Daisuke

AU - Fukuda, Kenji

AU - Kataoka, Hiroharu

AU - Morita, Yoshiaki

AU - Nishimura, Kunihiro

AU - Kawamura, Yoichiro

AU - Iihara, Koji

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Objective We evaluated carotid artery outward remodeling and plaque relative signal intensity (rSI) using T1-weighted magnetic resonance imaging (T1-MRI) to investigate their clinical significance in carotid revascularization. Methods From 86 patients undergoing carotid endarterectomy (CEA) or carotid artery stenting (CAS), 88 lesions (51 lesions treated with CEA and 37 lesions treated with CAS) were analyzed retrospectively. We evaluated the preoperative carotid artery remodeling index (CRI), determined by a ratio of the external cross-sectional vessel area at maximum stenosis and the reference cross-sectional vessel area at the distal portion of the internal carotid artery, and the plaque rSI, which is quantified as the ratio between the signal intensities of plaque and adjacent muscle using T1-MRI. We divided carotid lesions into four groups using the median values of CRI and rSI: L/L (CRI < 1.8, rSI < 2.5), H/L (CRI ≥ 1.8, rSI < 2.5), L/H (CRI < 1.8, rSI ≥ 2.5), and H/H (CRI ≥ 1.8, rSI ≥ 2.5). The primary end point was detection of acute ipsilateral ischemia on diffusion-weighted imaging (DWI) within 72 hours of treatment. Results Mean CRI and rSI were significantly higher in lesions treated with CEA than in those treated with CAS. Postoperative DWI abnormalities were observed in 4 CEA cases (7.8%) and 10 CAS cases (27.0%) (P =.01). In the CAS group, the frequency of DWI abnormalities was 5.5% for the L/L, 40.0% for the H/L and L/H, and 55.5% for the H/H group (P =.009). Multivariate analysis showed that the degree of stenosis and H/H lesion were independent risk factors for cerebral embolism. No correlation was found between plaque parameters and postoperative DWI findings in the CEA group. Conclusions CRI and rSI provide complementary information for the prediction of high-risk plaques associated with CAS but not with CEA. Preoperative evaluation with T1-MRI facilitates the selection of a treatment strategy for carotid artery stenosis.

AB - Objective We evaluated carotid artery outward remodeling and plaque relative signal intensity (rSI) using T1-weighted magnetic resonance imaging (T1-MRI) to investigate their clinical significance in carotid revascularization. Methods From 86 patients undergoing carotid endarterectomy (CEA) or carotid artery stenting (CAS), 88 lesions (51 lesions treated with CEA and 37 lesions treated with CAS) were analyzed retrospectively. We evaluated the preoperative carotid artery remodeling index (CRI), determined by a ratio of the external cross-sectional vessel area at maximum stenosis and the reference cross-sectional vessel area at the distal portion of the internal carotid artery, and the plaque rSI, which is quantified as the ratio between the signal intensities of plaque and adjacent muscle using T1-MRI. We divided carotid lesions into four groups using the median values of CRI and rSI: L/L (CRI < 1.8, rSI < 2.5), H/L (CRI ≥ 1.8, rSI < 2.5), L/H (CRI < 1.8, rSI ≥ 2.5), and H/H (CRI ≥ 1.8, rSI ≥ 2.5). The primary end point was detection of acute ipsilateral ischemia on diffusion-weighted imaging (DWI) within 72 hours of treatment. Results Mean CRI and rSI were significantly higher in lesions treated with CEA than in those treated with CAS. Postoperative DWI abnormalities were observed in 4 CEA cases (7.8%) and 10 CAS cases (27.0%) (P =.01). In the CAS group, the frequency of DWI abnormalities was 5.5% for the L/L, 40.0% for the H/L and L/H, and 55.5% for the H/H group (P =.009). Multivariate analysis showed that the degree of stenosis and H/H lesion were independent risk factors for cerebral embolism. No correlation was found between plaque parameters and postoperative DWI findings in the CEA group. Conclusions CRI and rSI provide complementary information for the prediction of high-risk plaques associated with CAS but not with CEA. Preoperative evaluation with T1-MRI facilitates the selection of a treatment strategy for carotid artery stenosis.

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