TY - JOUR
T1 - Evaluation of cellular adhesions on silicone and poly(methyl methacrylate) intraocular lenses in monkey eyes
T2 - An electron microscopic study
AU - Ohnishi, Yoshitaka
AU - Yoshitomi, Takeshi
AU - Sakamoto, Taiji
AU - Fujisawa, Kimihiko
AU - Ishibashi, Tatsuro
N1 - Funding Information:
Supported in part by a grant (12671718) from the Ministry of Education, Science, Technology, Sports and Culture in Japan.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - Purpose: To assess the biocompatibility of intraocular lens (IOL) material by studying the number of cells adhering to IOLs in monkey eyes. Setting: Department of Ophthalmology, Kyushu University, Fukuoka, Japan. Methods: Silicone or poly(methyl methacrylate) (PMMA) IOL implantation was performed in 21 monkeys. One eye of each animal had surgery. The IOL-implanted eyes were enucleated 1, 2, 3, 5, and 7 days and 1, 3, 4, 5, and 9 months after the procedure. One eye was studied at each time. Cells on the anterior IOL surface were photographed using a scanning electron microscope, counted and assessed with NEC, Graphtec, and Nikon equipment, and then observed using a transmission electron microscope. Results: Leukocytes, macrophages, and giant cells were found on the anterior IOL surface. Numerous cells were observed on the PMMA IOLs in the early postoperative period; they gradually decreased. Few cells were seen on the silicone IOLs during the course of the study. The giant cells became larger during the postoperative period. Conclusion: The foreign-body reaction to silicone IOLs in monkey eyes was less than that to PMMA IOLs.
AB - Purpose: To assess the biocompatibility of intraocular lens (IOL) material by studying the number of cells adhering to IOLs in monkey eyes. Setting: Department of Ophthalmology, Kyushu University, Fukuoka, Japan. Methods: Silicone or poly(methyl methacrylate) (PMMA) IOL implantation was performed in 21 monkeys. One eye of each animal had surgery. The IOL-implanted eyes were enucleated 1, 2, 3, 5, and 7 days and 1, 3, 4, 5, and 9 months after the procedure. One eye was studied at each time. Cells on the anterior IOL surface were photographed using a scanning electron microscope, counted and assessed with NEC, Graphtec, and Nikon equipment, and then observed using a transmission electron microscope. Results: Leukocytes, macrophages, and giant cells were found on the anterior IOL surface. Numerous cells were observed on the PMMA IOLs in the early postoperative period; they gradually decreased. Few cells were seen on the silicone IOLs during the course of the study. The giant cells became larger during the postoperative period. Conclusion: The foreign-body reaction to silicone IOLs in monkey eyes was less than that to PMMA IOLs.
UR - http://www.scopus.com/inward/record.url?scp=0035205740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035205740&partnerID=8YFLogxK
U2 - 10.1016/S0886-3350(01)00961-0
DO - 10.1016/S0886-3350(01)00961-0
M3 - Article
C2 - 11738922
AN - SCOPUS:0035205740
VL - 27
SP - 2036
EP - 2040
JO - Journal of Cataract and Refractive Surgery
JF - Journal of Cataract and Refractive Surgery
SN - 0886-3350
IS - 12
ER -