Evaluation of chronic ischemic heart disease with myocardial perfusion and regional contraction analysis by contrast-enhanced 256-MSCT

Ko Higuchi, Michinobu Nagao, Yoshio Matsuo, Takeshi Kamitani, Masato Yonezawa, Mikako Jinnouchi, Yuzo Yamasaki, Koichiro Abe, Shingo Baba, Yasushi Mukai, Taiki Higo, Kenji Sunagawa, Hiroshi Honda

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Abstract

Purpose: To investigate myocardial viability in chronic ischemic heart disease by myocardial perfusion and regional contraction analysis using 256-slice MSCT coronary angiography (CCTA). Methods: In 30 patients with prior myocardial infarction (MI), CCTA with retrospective ECG-gating and stress-redistribution thallium-201 SPECT were performed. Using the same raw data as used for CCTA, myocardial perfusion imaging (CT-MPI) was reconstructed at four phases during the cardiac cycle. Mean myocardial attenuation and wall thickness at end-systole and end-diastole were measured in the MI areas depicted by SPECT, and they were compared between viable and non-viable segments categorized by SPECT. Results: End-systolic thickness was significantly greater for viable than for non-viable segments (12.0 ± 3.2 vs. 9.6 ± 3.5 mm, p = 0.0017). There was no difference in end-diastolic thickness. Myocardial attenuation was significantly higher for viable than for non-viable segments in the subendocardium (62 ± 13 vs. 70 ± 11 HU, p = 0.003) and the epicardium (65 ± 13 vs. 80 ± 15 HU, p = 0.0002). Conclusion: The systolic wall thinning and epicardial low-attenuation areas were the indicative findings of CT-MPI for non-viable segments in the prior MI.

Original languageEnglish
Pages (from-to)123-132
Number of pages10
JournalJapanese Journal of Radiology
Volume31
Issue number2
DOIs
Publication statusPublished - Feb 1 2013

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Single-Photon Emission-Computed Tomography
Myocardial Ischemia
Myocardial Perfusion Imaging
Perfusion
Myocardial Infarction
Diastole
Thallium
Systole
Pericardium
Coronary Angiography
Electrocardiography

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Evaluation of chronic ischemic heart disease with myocardial perfusion and regional contraction analysis by contrast-enhanced 256-MSCT. / Higuchi, Ko; Nagao, Michinobu; Matsuo, Yoshio; Kamitani, Takeshi; Yonezawa, Masato; Jinnouchi, Mikako; Yamasaki, Yuzo; Abe, Koichiro; Baba, Shingo; Mukai, Yasushi; Higo, Taiki; Sunagawa, Kenji; Honda, Hiroshi.

In: Japanese Journal of Radiology, Vol. 31, No. 2, 01.02.2013, p. 123-132.

Research output: Contribution to journalArticle

Higuchi, Ko ; Nagao, Michinobu ; Matsuo, Yoshio ; Kamitani, Takeshi ; Yonezawa, Masato ; Jinnouchi, Mikako ; Yamasaki, Yuzo ; Abe, Koichiro ; Baba, Shingo ; Mukai, Yasushi ; Higo, Taiki ; Sunagawa, Kenji ; Honda, Hiroshi. / Evaluation of chronic ischemic heart disease with myocardial perfusion and regional contraction analysis by contrast-enhanced 256-MSCT. In: Japanese Journal of Radiology. 2013 ; Vol. 31, No. 2. pp. 123-132.
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AU - Yonezawa, Masato

AU - Jinnouchi, Mikako

AU - Yamasaki, Yuzo

AU - Abe, Koichiro

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