Evaluation of drug carrier responding to Matrix Metalloproteinase II in cancer cell

Kentaro Nishi, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Matrix Metalloproteinase II (MMP II) plays a key role when cancer cells perform invasion and metastasis by degrading a collagen. Moreover, the expression of this proteinase is enhanced in bone destruction in rheumatoid arthritis. We succeeded in developing novel drug delivery system that can respond to MMP II. In our DDS, the micelle which is formed from amphiphilic copolymers is used as a drug carrier. The copolymer is composed of hydrophobic polymer main chain and hydrophilic peptide side chain which is linked to the main chain with substrate of MMP II. The micelle will be coagulated by digestion of the substrate by MMP II that is enhanced in cancer invasion and rheumatoid and will release the incorporated drug. To realize the DDS, we synthesized the copolymers and evaluated in vitro.

Original languageEnglish
Title of host publication55th SPSJ Symposium on Macromolecules
Pages5461-5462
Number of pages2
Volume55
Edition2
Publication statusPublished - 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sep 20 2006Sep 22 2006

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period9/20/069/22/06

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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  • Cite this

    Nishi, K., Mori, T., Niidome, T., & Katayama, Y. (2006). Evaluation of drug carrier responding to Matrix Metalloproteinase II in cancer cell. In 55th SPSJ Symposium on Macromolecules (2 ed., Vol. 55, pp. 5461-5462)