Evaluation of Glucose Tolerance in Families with Hyperproinsulinemia and Mutant Insulin Receptors

Naoki Nakashima, Tomoya Miyamura, Tsukasa Yamashita, Toshihiko Hashimoto, Fumio Umeda, Hajime Nawata, Nobunori Aso, Toshiharu Motomatsu

Research output: Contribution to journalArticle

Abstract

Families with hyperproinsulinemia may be considered a model of excess secretion of insulin by pancreatic beta cells, and those with mutant insulin receptors as a model of insulin resistance. We evaluated members of two families, one with hyperproinsulinemia (His65-proinsulin) and the other with mutant insulin receptors (His252-insulin receptor), employing the oral glucose tolerance test (OGTT) and other parameters of glucose metabolism. Alterations in glucose tolerance were observed over a five-year period. Genotypes of relevant mutations were reflected by the fasting serum CPR/IRI molar ratio in the family with hyperproinsulinemia, and by the degree of abnormality in serum IRI on OGTT in the family with mutant insulin receptors. In both families, a low insulin secretory response, indicating pancreatic beta cell dysfunction, might exacerbate glucose intolerance. We conclude that not only the mutations, but also other genetic or environmental factors, may contribute to glucose intolerance in both families.

Original languageEnglish
Pages (from-to)707-714
Number of pages8
JournalJournal of the Japan Diabetes Society
Volume36
Issue number9
DOIs
Publication statusPublished - Jan 1 1993

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Insulin Receptor
Glucose
Glucose Intolerance
Insulin-Secreting Cells
Glucose Tolerance Test
Insulin
Proinsulin
Mutation
Cardiopulmonary Resuscitation
Serum
Insulin Resistance
Hyperproinsulinemia
Fasting
Genotype

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Evaluation of Glucose Tolerance in Families with Hyperproinsulinemia and Mutant Insulin Receptors. / Nakashima, Naoki; Miyamura, Tomoya; Yamashita, Tsukasa; Hashimoto, Toshihiko; Umeda, Fumio; Nawata, Hajime; Aso, Nobunori; Motomatsu, Toshiharu.

In: Journal of the Japan Diabetes Society, Vol. 36, No. 9, 01.01.1993, p. 707-714.

Research output: Contribution to journalArticle

Nakashima, N, Miyamura, T, Yamashita, T, Hashimoto, T, Umeda, F, Nawata, H, Aso, N & Motomatsu, T 1993, 'Evaluation of Glucose Tolerance in Families with Hyperproinsulinemia and Mutant Insulin Receptors', Journal of the Japan Diabetes Society, vol. 36, no. 9, pp. 707-714. https://doi.org/10.11213/tonyobyo1958.36.707
Nakashima, Naoki ; Miyamura, Tomoya ; Yamashita, Tsukasa ; Hashimoto, Toshihiko ; Umeda, Fumio ; Nawata, Hajime ; Aso, Nobunori ; Motomatsu, Toshiharu. / Evaluation of Glucose Tolerance in Families with Hyperproinsulinemia and Mutant Insulin Receptors. In: Journal of the Japan Diabetes Society. 1993 ; Vol. 36, No. 9. pp. 707-714.
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