Abstract
We developed a magnetic nanoparticle (MNP) imaging system that uses the harmonic signals of MNPs on the basis of their nonlinear magnetization curves. Since the interference of the excitation field can be significantly decreased by measuring the harmonic signals, the detection sensitivity can be improved. First, we have characterized the nonlinear properties of MNPs in order to evaluate the harmonic signals. We clarified what proportion of MNPs contributes to the harmonic signal. It is important to choose a sample having a large portion of MNPs with large magnetic moment and short relaxation time for the harmonic signal-based detection. Then, we measured a contour map of the signal field from the MNPs with our simple detection system using second harmonic signal. We could detect 100 μg of MNPs located at z = 25 mm below the pickup coil with a high signal-to-noise ratio. Analyzing the contour map using a mathematical technique called singular value decomposition (SVD), we could clearly distinguish two MNP samples separated by ?x = 25 mm and located at z = 25 mm. This simple detection system will be useful for medical applications such as sentinel lymph node detection.
| Original language | English |
|---|---|
| Journal | IEEJ Transactions on Fundamentals and Materials |
| Volume | 133 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jul 12 2013 |
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All Science Journal Classification (ASJC) codes
- Electrical and Electronic Engineering
Cite this
Evaluation of harmonic signals from magnetic nanoparticles and application to magnetic nanoparticle imaging. / Yoshida, Takashi; Othman, Nurmiza Binti; Tsubaki, Takuya; Enpuku, Keiji.
In: IEEJ Transactions on Fundamentals and Materials, Vol. 133, No. 6, 12.07.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of harmonic signals from magnetic nanoparticles and application to magnetic nanoparticle imaging
AU - Yoshida, Takashi
AU - Othman, Nurmiza Binti
AU - Tsubaki, Takuya
AU - Enpuku, Keiji
PY - 2013/7/12
Y1 - 2013/7/12
N2 - We developed a magnetic nanoparticle (MNP) imaging system that uses the harmonic signals of MNPs on the basis of their nonlinear magnetization curves. Since the interference of the excitation field can be significantly decreased by measuring the harmonic signals, the detection sensitivity can be improved. First, we have characterized the nonlinear properties of MNPs in order to evaluate the harmonic signals. We clarified what proportion of MNPs contributes to the harmonic signal. It is important to choose a sample having a large portion of MNPs with large magnetic moment and short relaxation time for the harmonic signal-based detection. Then, we measured a contour map of the signal field from the MNPs with our simple detection system using second harmonic signal. We could detect 100 μg of MNPs located at z = 25 mm below the pickup coil with a high signal-to-noise ratio. Analyzing the contour map using a mathematical technique called singular value decomposition (SVD), we could clearly distinguish two MNP samples separated by ?x = 25 mm and located at z = 25 mm. This simple detection system will be useful for medical applications such as sentinel lymph node detection.
AB - We developed a magnetic nanoparticle (MNP) imaging system that uses the harmonic signals of MNPs on the basis of their nonlinear magnetization curves. Since the interference of the excitation field can be significantly decreased by measuring the harmonic signals, the detection sensitivity can be improved. First, we have characterized the nonlinear properties of MNPs in order to evaluate the harmonic signals. We clarified what proportion of MNPs contributes to the harmonic signal. It is important to choose a sample having a large portion of MNPs with large magnetic moment and short relaxation time for the harmonic signal-based detection. Then, we measured a contour map of the signal field from the MNPs with our simple detection system using second harmonic signal. We could detect 100 μg of MNPs located at z = 25 mm below the pickup coil with a high signal-to-noise ratio. Analyzing the contour map using a mathematical technique called singular value decomposition (SVD), we could clearly distinguish two MNP samples separated by ?x = 25 mm and located at z = 25 mm. This simple detection system will be useful for medical applications such as sentinel lymph node detection.
UR - http://www.scopus.com/inward/record.url?scp=84879878575&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879878575&partnerID=8YFLogxK
U2 - 10.1541/ieejfms.133.344
DO - 10.1541/ieejfms.133.344
M3 - Article
VL - 133
JO - IEEJ Transactions on Fundamentals and Materials
JF - IEEJ Transactions on Fundamentals and Materials
SN - 0385-4205
IS - 6
ER -