Evaluation of hydroxyapatite-putty as a hemostatic agent

Y. Momota, Y. Miyamoto, Kunio Ishikawa, M. Takechi, T. Yuasa, T. Toh, M. Nagayama, K. Suzuki

Research output: Contribution to journalArticle

Abstract

Although bone wax is often used as a hemostatic agent for bone in surgery, some problems in biocompatibility have been pointed out. Therefore, we have evaluated hydroxyapatite-putty (HAP-putty) as a hemostatic agent for bone. Adhesive strength of HAP-putty to bone increased with the amount of sodium alginate, reaching maximum value in case of containing 8% sodium alginate. An actual hemostatic ability of HAP-putty was evaluated using rabbits. Bleeding from bone was arrested within 3 minutes. Thus, HAP-putty showed excellent hemostatic ability. Soft tissue response to HAP-putty was evaluated in rabbit subcutaneous tissue. Histological observation revealed slight inflammatory response around HAP-putty. HAP-putty partially transformed to HAP 24 hours after the implantation. In conclusion, HAP-putty could be a useful hemostatic agent for bone due to its good hemostatic ability and excellent biocompatibility.

Original languageEnglish
Pages (from-to)849-852
Number of pages4
JournalKey Engineering Materials
Volume192-195
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Putty
Hemostatics
Durapatite
Hydroxyapatite
Bone
Sodium alginate
Biocompatibility
Tissue
Waxes
Surgery
Adhesives

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Ceramics and Composites

Cite this

Momota, Y., Miyamoto, Y., Ishikawa, K., Takechi, M., Yuasa, T., Toh, T., ... Suzuki, K. (2001). Evaluation of hydroxyapatite-putty as a hemostatic agent. Key Engineering Materials, 192-195, 849-852.

Evaluation of hydroxyapatite-putty as a hemostatic agent. / Momota, Y.; Miyamoto, Y.; Ishikawa, Kunio; Takechi, M.; Yuasa, T.; Toh, T.; Nagayama, M.; Suzuki, K.

In: Key Engineering Materials, Vol. 192-195, 2001, p. 849-852.

Research output: Contribution to journalArticle

Momota, Y, Miyamoto, Y, Ishikawa, K, Takechi, M, Yuasa, T, Toh, T, Nagayama, M & Suzuki, K 2001, 'Evaluation of hydroxyapatite-putty as a hemostatic agent', Key Engineering Materials, vol. 192-195, pp. 849-852.
Momota Y, Miyamoto Y, Ishikawa K, Takechi M, Yuasa T, Toh T et al. Evaluation of hydroxyapatite-putty as a hemostatic agent. Key Engineering Materials. 2001;192-195:849-852.
Momota, Y. ; Miyamoto, Y. ; Ishikawa, Kunio ; Takechi, M. ; Yuasa, T. ; Toh, T. ; Nagayama, M. ; Suzuki, K. / Evaluation of hydroxyapatite-putty as a hemostatic agent. In: Key Engineering Materials. 2001 ; Vol. 192-195. pp. 849-852.
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AU - Nagayama, M.

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