Abstract
Although bone wax is often used as a hemostatic agent for bone in surgery, some problems in biocompatibility have been pointed out. Therefore, we have evaluated hydroxyapatite-putty (HAP-putty) as a hemostatic agent for bone. Adhesive strength of HAP-putty to bone increased with the amount of sodium alginate, reaching maximum value in case of containing 8% sodium alginate. An actual hemostatic ability of HAP-putty was evaluated using rabbits. Bleeding from bone was arrested within 3 minutes. Thus, HAP-putty showed excellent hemostatic ability. Soft tissue response to HAP-putty was evaluated in rabbit subcutaneous tissue. Histological observation revealed slight inflammatory response around HAP-putty. HAP-putty partially transformed to HAP 24 hours after the implantation. In conclusion, HAP-putty could be a useful hemostatic agent for bone due to its good hemostatic ability and excellent biocompatibility.
| Original language | English |
|---|---|
| Pages (from-to) | 849-852 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 192-195 |
| Publication status | Published - 2001 |
| Externally published | Yes |
| Event | 13th international Symposium on Ceramics in Medicine (BIOCERAMICS) - Bologna, Italy Duration: Nov 22 2000 → Nov 26 2000 |
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering