Evaluation of hydroxyapatite-putty as a hemostatic agent

Y. Momota, Y. Miyamoto, Kunio Ishikawa, M. Takechi, T. Yuasa, T. Toh, M. Nagayama, K. Suzuki

Research output: Contribution to journalArticle


Although bone wax is often used as a hemostatic agent for bone in surgery, some problems in biocompatibility have been pointed out. Therefore, we have evaluated hydroxyapatite-putty (HAP-putty) as a hemostatic agent for bone. Adhesive strength of HAP-putty to bone increased with the amount of sodium alginate, reaching maximum value in case of containing 8% sodium alginate. An actual hemostatic ability of HAP-putty was evaluated using rabbits. Bleeding from bone was arrested within 3 minutes. Thus, HAP-putty showed excellent hemostatic ability. Soft tissue response to HAP-putty was evaluated in rabbit subcutaneous tissue. Histological observation revealed slight inflammatory response around HAP-putty. HAP-putty partially transformed to HAP 24 hours after the implantation. In conclusion, HAP-putty could be a useful hemostatic agent for bone due to its good hemostatic ability and excellent biocompatibility.

Original languageEnglish
Pages (from-to)849-852
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - 2001
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Ceramics and Composites

Cite this

Momota, Y., Miyamoto, Y., Ishikawa, K., Takechi, M., Yuasa, T., Toh, T., ... Suzuki, K. (2001). Evaluation of hydroxyapatite-putty as a hemostatic agent. Key Engineering Materials, 192-195, 849-852.