Evaluation of mobility of 2-N-tert-butylaminoxyladenosine incorporated into oligodeoxynucleotides.

Yoshitaka Higuchi, Mariko Aso, Ryouko Harada, Noboru Koga, Hiroshi Suemune

Research output: Contribution to journalArticle

Abstract

We synthesized oligodeoxynucleotide (ODN, 3) containing 2-N-tert-butylaminoxyladenosine (1) and studied EPR spectra of 3 and its duplexes. The h(+)/h(0) values in the EPR spectra of duplexes between 3 and 5-8 well correlated with Tm values. We also synthesized ODN 4 containing 2, which has a cyclic aminoxyl via a linker, to compare with ODN 3. The h(+)/h(0) values in the EPR spectra of duplexes between 4 and 5-8 did not correlate with Tm values. These results indicate that 1 has a potential to monitor of motion of the nucleobase.

Original languageEnglish
Pages (from-to)151-152
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number53
DOIs
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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