Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma

H. Kurokawa, K. Miura, Yoshihisa Yamashita, S. Tokudome, T. Murata, M. Kajiyama

Research output: Contribution to journalArticle

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Abstract

In the present study, we investigated the clinical and histopathological effects of CP therapy consisting of cisplatin (CDDP 50 mg/m2) or carboplatin (CBDCA 300 mg/m2) and peplomycin (PEP 5 mg/day) for 25 patients with oral squamous cell carcinoma. The effects of treatment and associated complications were as follows: 1) Complete response (CR) was achieved in 8 and partial response (PR) in 14 of the 25 cases. The overall clinical response rate was 88%. The histological response rate was 64%. 2) The clinical effects were not always consistent with the histopathological effects. There were discrepancies between the clinical and histopathological effects, especially in PR determined by clinical findings. 3) The principal adverse reaction was gastrointestinal disturbances, but symptoms were able to be controlled. Signs of hematologic toxicity and renal disturbance were mild and did not preclude the continuance of therapy. The results of this study indicated that neo-adjuvant chemotherapy with CDDP and PEP was highly effective for the local control of oral squamous cell carcinoma.

Original languageEnglish
Pages (from-to)1273-1278
Number of pages6
JournalJapanese Journal of Cancer and Chemotherapy
Volume24
Issue number10
Publication statusPublished - Sep 24 1997

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Adjuvant Chemotherapy
Squamous Cell Carcinoma
Carboplatin
Peplomycin
Cisplatin
Therapeutics
Kidney
Peptamen

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kurokawa, H., Miura, K., Yamashita, Y., Tokudome, S., Murata, T., & Kajiyama, M. (1997). Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma. Japanese Journal of Cancer and Chemotherapy, 24(10), 1273-1278.

Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma. / Kurokawa, H.; Miura, K.; Yamashita, Yoshihisa; Tokudome, S.; Murata, T.; Kajiyama, M.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 24, No. 10, 24.09.1997, p. 1273-1278.

Research output: Contribution to journalArticle

Kurokawa, H, Miura, K, Yamashita, Y, Tokudome, S, Murata, T & Kajiyama, M 1997, 'Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma', Japanese Journal of Cancer and Chemotherapy, vol. 24, no. 10, pp. 1273-1278.
Kurokawa H, Miura K, Yamashita Y, Tokudome S, Murata T, Kajiyama M. Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma. Japanese Journal of Cancer and Chemotherapy. 1997 Sep 24;24(10):1273-1278.
Kurokawa, H. ; Miura, K. ; Yamashita, Yoshihisa ; Tokudome, S. ; Murata, T. ; Kajiyama, M. / Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma. In: Japanese Journal of Cancer and Chemotherapy. 1997 ; Vol. 24, No. 10. pp. 1273-1278.
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