Evaluation of scatter limitation correction: A new method of correcting photopenic artifacts caused by patient motion during whole-body PET/CT imaging

Kenta Miwa, Takuro Umeda, Taisuke Murata, Kei Wagatsuma, Noriaki Miyaji, Takashi Terauchi, Mitsuru Koizumi, Masayuki Sasaki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective Overcorrection of scatter caused by patient motion during whole-body PET/computed tomography (CT) imaging can induce the appearance of photopenic artifacts in the PET images. The present study aimed to quantify the accuracy of scatter limitation correction (SLC) for eliminating photopenic artifacts. Methods This study analyzed photopenic artifacts in 18F-fluorodeoxyglucose (18F-FDG) PET/CT images acquired from 12 patients and from a National Electrical Manufacturers Association phantom with two peripheral plastic bottles that simulated the human body and arms, respectively. The phantom comprised a sphere (diameter, 10 or 37 mm) containing fluorine-18 solutions with target-to-background ratios of 2, 4, and 8. The plastic bottles were moved 10 cm posteriorly between CT and PET acquisitions. All PETdata were reconstructed using model-based scatter correction (SC), no scatter correction (NSC), and SLC, and the presence or absence of artifacts on the PET images was visually evaluated. The SC and SLC images were also semiquantitatively evaluated using standardized uptake values (SUVs). Results Photopenic artifacts were not recognizable in any NSC and SLC image from all 12 patients in the clinical study. The SUVmax of mismatched SLC PET/CT images were almost equal to those of matched SC and SLC PET/CT images. Applying NSC and SLC substantially eliminated the photopenic artifacts on SC PET images in the phantom study. SLC improved the activity concentration of the sphere for all target-to-background ratios. The highest %errors of the 10 and 37-mm spheres were 93.3 and 58.3%, respectively, for mismatched SC, and 73.2 and 22.0%, respectively, for mismatched SLC. Conclusion Photopenic artifacts caused by SC error induced by CTand PET image misalignment were corrected using SLC, indicating that this method is useful and practical for clinical qualitative and quantitative PET/CT assessment.

Original languageEnglish
Pages (from-to)147-154
Number of pages8
JournalNuclear Medicine Communications
Volume37
Issue number2
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Artifacts
Tomography
Plastics
Fluorine
Fluorodeoxyglucose F18
Human Body

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Evaluation of scatter limitation correction : A new method of correcting photopenic artifacts caused by patient motion during whole-body PET/CT imaging. / Miwa, Kenta; Umeda, Takuro; Murata, Taisuke; Wagatsuma, Kei; Miyaji, Noriaki; Terauchi, Takashi; Koizumi, Mitsuru; Sasaki, Masayuki.

In: Nuclear Medicine Communications, Vol. 37, No. 2, 01.01.2016, p. 147-154.

Research output: Contribution to journalArticle

Miwa, Kenta ; Umeda, Takuro ; Murata, Taisuke ; Wagatsuma, Kei ; Miyaji, Noriaki ; Terauchi, Takashi ; Koizumi, Mitsuru ; Sasaki, Masayuki. / Evaluation of scatter limitation correction : A new method of correcting photopenic artifacts caused by patient motion during whole-body PET/CT imaging. In: Nuclear Medicine Communications. 2016 ; Vol. 37, No. 2. pp. 147-154.
@article{1d5809c5ecaa4092992165e1c7915289,
title = "Evaluation of scatter limitation correction: A new method of correcting photopenic artifacts caused by patient motion during whole-body PET/CT imaging",
abstract = "Objective Overcorrection of scatter caused by patient motion during whole-body PET/computed tomography (CT) imaging can induce the appearance of photopenic artifacts in the PET images. The present study aimed to quantify the accuracy of scatter limitation correction (SLC) for eliminating photopenic artifacts. Methods This study analyzed photopenic artifacts in 18F-fluorodeoxyglucose (18F-FDG) PET/CT images acquired from 12 patients and from a National Electrical Manufacturers Association phantom with two peripheral plastic bottles that simulated the human body and arms, respectively. The phantom comprised a sphere (diameter, 10 or 37 mm) containing fluorine-18 solutions with target-to-background ratios of 2, 4, and 8. The plastic bottles were moved 10 cm posteriorly between CT and PET acquisitions. All PETdata were reconstructed using model-based scatter correction (SC), no scatter correction (NSC), and SLC, and the presence or absence of artifacts on the PET images was visually evaluated. The SC and SLC images were also semiquantitatively evaluated using standardized uptake values (SUVs). Results Photopenic artifacts were not recognizable in any NSC and SLC image from all 12 patients in the clinical study. The SUVmax of mismatched SLC PET/CT images were almost equal to those of matched SC and SLC PET/CT images. Applying NSC and SLC substantially eliminated the photopenic artifacts on SC PET images in the phantom study. SLC improved the activity concentration of the sphere for all target-to-background ratios. The highest {\%}errors of the 10 and 37-mm spheres were 93.3 and 58.3{\%}, respectively, for mismatched SC, and 73.2 and 22.0{\%}, respectively, for mismatched SLC. Conclusion Photopenic artifacts caused by SC error induced by CTand PET image misalignment were corrected using SLC, indicating that this method is useful and practical for clinical qualitative and quantitative PET/CT assessment.",
author = "Kenta Miwa and Takuro Umeda and Taisuke Murata and Kei Wagatsuma and Noriaki Miyaji and Takashi Terauchi and Mitsuru Koizumi and Masayuki Sasaki",
year = "2016",
month = "1",
day = "1",
doi = "10.1097/MNM.0000000000000403",
language = "English",
volume = "37",
pages = "147--154",
journal = "Nuclear Medicine Communications",
issn = "0143-3636",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Evaluation of scatter limitation correction

T2 - A new method of correcting photopenic artifacts caused by patient motion during whole-body PET/CT imaging

AU - Miwa, Kenta

AU - Umeda, Takuro

AU - Murata, Taisuke

AU - Wagatsuma, Kei

AU - Miyaji, Noriaki

AU - Terauchi, Takashi

AU - Koizumi, Mitsuru

AU - Sasaki, Masayuki

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Objective Overcorrection of scatter caused by patient motion during whole-body PET/computed tomography (CT) imaging can induce the appearance of photopenic artifacts in the PET images. The present study aimed to quantify the accuracy of scatter limitation correction (SLC) for eliminating photopenic artifacts. Methods This study analyzed photopenic artifacts in 18F-fluorodeoxyglucose (18F-FDG) PET/CT images acquired from 12 patients and from a National Electrical Manufacturers Association phantom with two peripheral plastic bottles that simulated the human body and arms, respectively. The phantom comprised a sphere (diameter, 10 or 37 mm) containing fluorine-18 solutions with target-to-background ratios of 2, 4, and 8. The plastic bottles were moved 10 cm posteriorly between CT and PET acquisitions. All PETdata were reconstructed using model-based scatter correction (SC), no scatter correction (NSC), and SLC, and the presence or absence of artifacts on the PET images was visually evaluated. The SC and SLC images were also semiquantitatively evaluated using standardized uptake values (SUVs). Results Photopenic artifacts were not recognizable in any NSC and SLC image from all 12 patients in the clinical study. The SUVmax of mismatched SLC PET/CT images were almost equal to those of matched SC and SLC PET/CT images. Applying NSC and SLC substantially eliminated the photopenic artifacts on SC PET images in the phantom study. SLC improved the activity concentration of the sphere for all target-to-background ratios. The highest %errors of the 10 and 37-mm spheres were 93.3 and 58.3%, respectively, for mismatched SC, and 73.2 and 22.0%, respectively, for mismatched SLC. Conclusion Photopenic artifacts caused by SC error induced by CTand PET image misalignment were corrected using SLC, indicating that this method is useful and practical for clinical qualitative and quantitative PET/CT assessment.

AB - Objective Overcorrection of scatter caused by patient motion during whole-body PET/computed tomography (CT) imaging can induce the appearance of photopenic artifacts in the PET images. The present study aimed to quantify the accuracy of scatter limitation correction (SLC) for eliminating photopenic artifacts. Methods This study analyzed photopenic artifacts in 18F-fluorodeoxyglucose (18F-FDG) PET/CT images acquired from 12 patients and from a National Electrical Manufacturers Association phantom with two peripheral plastic bottles that simulated the human body and arms, respectively. The phantom comprised a sphere (diameter, 10 or 37 mm) containing fluorine-18 solutions with target-to-background ratios of 2, 4, and 8. The plastic bottles were moved 10 cm posteriorly between CT and PET acquisitions. All PETdata were reconstructed using model-based scatter correction (SC), no scatter correction (NSC), and SLC, and the presence or absence of artifacts on the PET images was visually evaluated. The SC and SLC images were also semiquantitatively evaluated using standardized uptake values (SUVs). Results Photopenic artifacts were not recognizable in any NSC and SLC image from all 12 patients in the clinical study. The SUVmax of mismatched SLC PET/CT images were almost equal to those of matched SC and SLC PET/CT images. Applying NSC and SLC substantially eliminated the photopenic artifacts on SC PET images in the phantom study. SLC improved the activity concentration of the sphere for all target-to-background ratios. The highest %errors of the 10 and 37-mm spheres were 93.3 and 58.3%, respectively, for mismatched SC, and 73.2 and 22.0%, respectively, for mismatched SLC. Conclusion Photopenic artifacts caused by SC error induced by CTand PET image misalignment were corrected using SLC, indicating that this method is useful and practical for clinical qualitative and quantitative PET/CT assessment.

UR - http://www.scopus.com/inward/record.url?scp=84953348005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953348005&partnerID=8YFLogxK

U2 - 10.1097/MNM.0000000000000403

DO - 10.1097/MNM.0000000000000403

M3 - Article

C2 - 26440565

AN - SCOPUS:84953348005

VL - 37

SP - 147

EP - 154

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

SN - 0143-3636

IS - 2

ER -