TY - JOUR
T1 - Evaluation of sub-microsecond recovery resonators for in vivo electron paramagnetic resonance imaging
AU - Hyodo, F.
AU - Subramanian, S.
AU - Devasahayam, N.
AU - Murugesan, R.
AU - Matsumoto, K.
AU - Mitchell, J. B.
AU - Krishna, M. C.
N1 - Funding Information:
This research was supported by the intramural research program of the NIH, NCI, and the Center for Cancer Research.
PY - 2008/2
Y1 - 2008/2
N2 - Time-domain (TD) electron paramagnetic resonance (EPR) imaging at 300 MHz for in vivo applications requires resonators with recovery times less than 1 μs after pulsed excitation to reliably capture the rapidly decaying free induction decay (FID). In this study, we tested the suitability of the Litz foil coil resonator (LCR), commonly used in MRI, for in vivo EPR/EPRI applications in the TD mode and compared with parallel coil resonator (PCR). In TD mode, the sensitivity of LCR was lower than that of the PCR. However, in continuous wave (CW) mode, the LCR showed better sensitivity. The RF homogeneity was similar in both the resonators. The axis of the RF magnetic field is transverse to the cylindrical axis of the LCR, making the resonator and the magnet co-axial. Therefore, the loading of animals, and placing of the anesthesia nose cone and temperature monitors was more convenient in the LCR compared to the PCR whose axis is perpendicular to the magnet axis.
AB - Time-domain (TD) electron paramagnetic resonance (EPR) imaging at 300 MHz for in vivo applications requires resonators with recovery times less than 1 μs after pulsed excitation to reliably capture the rapidly decaying free induction decay (FID). In this study, we tested the suitability of the Litz foil coil resonator (LCR), commonly used in MRI, for in vivo EPR/EPRI applications in the TD mode and compared with parallel coil resonator (PCR). In TD mode, the sensitivity of LCR was lower than that of the PCR. However, in continuous wave (CW) mode, the LCR showed better sensitivity. The RF homogeneity was similar in both the resonators. The axis of the RF magnetic field is transverse to the cylindrical axis of the LCR, making the resonator and the magnet co-axial. Therefore, the loading of animals, and placing of the anesthesia nose cone and temperature monitors was more convenient in the LCR compared to the PCR whose axis is perpendicular to the magnet axis.
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U2 - 10.1016/j.jmr.2007.11.004
DO - 10.1016/j.jmr.2007.11.004
M3 - Article
C2 - 18042414
AN - SCOPUS:38149097674
SN - 1090-7807
VL - 190
SP - 248
EP - 254
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
IS - 2
ER -