Evaluation of the immunomodulatory effects of fucoidan derived from cladosiphon okamuranus tokida in mice

Makoto Tomori, Takeaki Nagamine, Tomofumi Miyamoto, Masahiko Iha

Research output: Contribution to journalArticle

Abstract

Okinawa mozuku (Cladosiphon okamuranus Tokida) is an edible seaweed classified as brown algae and is a native species of the Ryukyu Islands in Japan. In recent years, the genomic decoding of Okinawa mozuku has been completed. Previous studies on the anti-inflammatory, antiviral, and antitumor properties of Okinawa mozuku have suggested that it affects the regulation of cellular and humoral immunity. The aim of the present study was to examine the immunoregulatory effect of fucoidan derived from Okinawa mozuku in mice. A product containing fucoidan (purity, 88.3%; molecular weight, 49.8 kDa) was developed from Okinawa mozuku and tested for its immunoregulatory effects in mice. The experimental animals were 8-week-old female BALB/c mice to which fucoidan (0, 102.5, 205.0, 410.0, and 1025.0 mg/kg) was administered orally continuously for six weeks. Immune cell proliferation, cytokine production, macrophage phagocytosis, and serum antibody concentration were measured. We found that immune cell proliferation, interleukin (IL)-2, macrophage phagocytes, and serum antibodies (IgM, -G, -A) increased significantly, but IL-4, -5, and IgE decreased significantly. These results indicated that fucoidan modulated cellular and humoral immunity.

Original languageEnglish
Article number547
JournalMarine Drugs
Volume17
Issue number10
DOIs
Publication statusPublished - Sep 24 2019

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Humoral Immunity
Cellular Immunity
Macrophages
Cell Proliferation
Phaeophyta
Seaweed
Antibodies
Interleukin-5
Phagocytes
Serum
Phagocytosis
Islands
Interleukin-4
Immunoglobulin E
Interleukin-2
Antiviral Agents
Immunoglobulin M
Japan
Anti-Inflammatory Agents
Molecular Weight

All Science Journal Classification (ASJC) codes

  • Drug Discovery

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Evaluation of the immunomodulatory effects of fucoidan derived from cladosiphon okamuranus tokida in mice. / Tomori, Makoto; Nagamine, Takeaki; Miyamoto, Tomofumi; Iha, Masahiko.

In: Marine Drugs, Vol. 17, No. 10, 547, 24.09.2019.

Research output: Contribution to journalArticle

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