Evolutionary design of oscillatory genetic networks in silico

Yuki Naruse, Hiroyuki Hamada, Taizo Hanai, Hitoshi Iba

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The design of genetic networks has been studied for implementing desired biological systems, and in particular, some researchers have proposed automatic design methods using optimization techniques. However, it is difficult to implement genetic networks designed by previous methods due to overly simplified model descriptions whose parameters are infeasible in the real world. Additionally, the methods do not ensure robustness against parameter perturbation. In this paper, we propose a two-stage design method and a fitness function evaluating robustness to create genetic networks which can be implemented experimentally. Further, we suggest the knowledge about robust network structures from results of optimization.

Original languageEnglish
Title of host publication2015 IEEE Congress on Evolutionary Computation, CEC 2015 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1596-1603
Number of pages8
ISBN (Electronic)9781479974924
DOIs
Publication statusPublished - Sep 10 2015
EventIEEE Congress on Evolutionary Computation, CEC 2015 - Sendai, Japan
Duration: May 25 2015May 28 2015

Other

OtherIEEE Congress on Evolutionary Computation, CEC 2015
CountryJapan
CitySendai
Period5/25/155/28/15

Fingerprint

Genetic Network
Design Method
Robustness
Two-stage Design
Parameter Perturbation
Biological systems
Fitness Function
Biological Systems
Network Structure
Optimization Techniques
Optimization
Design
Model

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Computational Mathematics

Cite this

Naruse, Y., Hamada, H., Hanai, T., & Iba, H. (2015). Evolutionary design of oscillatory genetic networks in silico. In 2015 IEEE Congress on Evolutionary Computation, CEC 2015 - Proceedings (pp. 1596-1603). [7257078] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CEC.2015.7257078

Evolutionary design of oscillatory genetic networks in silico. / Naruse, Yuki; Hamada, Hiroyuki; Hanai, Taizo; Iba, Hitoshi.

2015 IEEE Congress on Evolutionary Computation, CEC 2015 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2015. p. 1596-1603 7257078.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Naruse, Y, Hamada, H, Hanai, T & Iba, H 2015, Evolutionary design of oscillatory genetic networks in silico. in 2015 IEEE Congress on Evolutionary Computation, CEC 2015 - Proceedings., 7257078, Institute of Electrical and Electronics Engineers Inc., pp. 1596-1603, IEEE Congress on Evolutionary Computation, CEC 2015, Sendai, Japan, 5/25/15. https://doi.org/10.1109/CEC.2015.7257078
Naruse Y, Hamada H, Hanai T, Iba H. Evolutionary design of oscillatory genetic networks in silico. In 2015 IEEE Congress on Evolutionary Computation, CEC 2015 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2015. p. 1596-1603. 7257078 https://doi.org/10.1109/CEC.2015.7257078
Naruse, Yuki ; Hamada, Hiroyuki ; Hanai, Taizo ; Iba, Hitoshi. / Evolutionary design of oscillatory genetic networks in silico. 2015 IEEE Congress on Evolutionary Computation, CEC 2015 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2015. pp. 1596-1603
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