Evolving strategies to prevent biliary strictures after living donor liver transplantation

T. Ikegami, Y. Soejima, K. Shirabe, A. Taketomi, T. Yoshizumi, H. Uchiyama, T. Fukuhara, T. Ikeda, Y. Maehara

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Abstract

Introduction The optimal surgical technique has not been elucidated that reduces the occurrence of biliary strictures after living donor liver transplantation (LDLT). Method We performed retrospective analysis of 193 consecutive LDLTs, including 78 right and 115 left lobe grafts. An external biliary stent was used for all of the cases. Results The overall 1-, 3-, and 5-year biliary stricturefree survival rates were 87.5%, 85.3%, and 85.3%, respectively. The 1- and 3-year biliary stricturefree survival rates for duct-to-duct reconstruction were 86.9% and 84.9%, and those for hepaticojejunostomy were 90.1% and 80.8%, respectively. A multivariate analysis revealed that the original number of graft bile ducts greater than the number of external stents, right lobe grafts, bile leaks, and recipient age older than 60 years represented the significant risk factors (P < .05) to develop a biliary stricture after LDLT. All cases with biliary strictures (n = 61) were initially managed nonsurgically, but 4 patients ultimately required interventions. Conclusions Biliary reconstruction in LDLT using an appropriate number of external stents resulted in fairly acceptable outcomes. However, not only the proper use of stents or graft selection, but also nonsurgical factors, are important factors that determine the incidence of biliary strictures after LDLT.

Original languageEnglish
Pages (from-to)3624-3629
Number of pages6
JournalTransplantation Proceedings
Volume42
Issue number9
DOIs
Publication statusPublished - Nov 1 2010

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Living Donors
Liver Transplantation
Stents
Pathologic Constriction
Transplants
Survival Rate
Bile Ducts
Bile
Multivariate Analysis
Incidence

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Evolving strategies to prevent biliary strictures after living donor liver transplantation. / Ikegami, T.; Soejima, Y.; Shirabe, K.; Taketomi, A.; Yoshizumi, T.; Uchiyama, H.; Fukuhara, T.; Ikeda, T.; Maehara, Y.

In: Transplantation Proceedings, Vol. 42, No. 9, 01.11.2010, p. 3624-3629.

Research output: Contribution to journalArticle

Ikegami, T, Soejima, Y, Shirabe, K, Taketomi, A, Yoshizumi, T, Uchiyama, H, Fukuhara, T, Ikeda, T & Maehara, Y 2010, 'Evolving strategies to prevent biliary strictures after living donor liver transplantation', Transplantation Proceedings, vol. 42, no. 9, pp. 3624-3629. https://doi.org/10.1016/j.transproceed.2010.07.091
Ikegami, T. ; Soejima, Y. ; Shirabe, K. ; Taketomi, A. ; Yoshizumi, T. ; Uchiyama, H. ; Fukuhara, T. ; Ikeda, T. ; Maehara, Y. / Evolving strategies to prevent biliary strictures after living donor liver transplantation. In: Transplantation Proceedings. 2010 ; Vol. 42, No. 9. pp. 3624-3629.
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