Exacerbation of diabetic retinopathy following systemic insulin-like growth factor-I. Report of a case

M. Shigetou, T. Sagawa, Tatsuro Ishibashi, Naoki Nakashima, F. Umeda, H. Nawata

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 19-year-old female had been diagnosed as diabetes mellitus 8 years before. She was identified as type A insulin resistance syndrome. She had hyperinsulinemia and hyperglycemia due to defect in the insulin receptor gene. She was given insulin-like growth factor-I (IGF-I). No retinopathy was present then. The blood sugar level decreased smoothly. Seven months after initiation of the treatment, proliferative retinopathy started to progress. Panretinal photocoagulation failed to prevent disc and retinal neovascularizations. Withdrawal of IGF-I was followed by rapid disappearance of neovascularizations. It appeared that IGF-I decreased the blood sugar level by its insulin-like effect and that it also induced fundus neovascularizations by its growth hormone-like effect on endothelial cells of retinal vessels.

Original languageEnglish
Pages (from-to)1251-1255
Number of pages5
JournalJapanese Journal of Clinical Ophthalmology
Volume51
Issue number6
Publication statusPublished - Jan 1 1997

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Diabetic Retinopathy
Insulin-Like Growth Factor I
Blood Glucose
Retinal Neovascularization
Retinal Vessels
Light Coagulation
Hyperinsulinism
Hyperglycemia
Growth Hormone
Insulin Resistance
Diabetes Mellitus
Endothelial Cells
Insulin
Genes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Exacerbation of diabetic retinopathy following systemic insulin-like growth factor-I. Report of a case. / Shigetou, M.; Sagawa, T.; Ishibashi, Tatsuro; Nakashima, Naoki; Umeda, F.; Nawata, H.

In: Japanese Journal of Clinical Ophthalmology, Vol. 51, No. 6, 01.01.1997, p. 1251-1255.

Research output: Contribution to journalArticle

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