Excess accumulation of body fat is related to dyslipidemia in normal-weight subjects

H. Ito, K. Nakasuga, A. Ohshima, Y. Sakai, Toru Maruyama, Y. Kaji, M. Harada, S. Jingu, M. Sakamoto

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

OBJECTIVE: To assess the relationship of fat mass (FM) and its distribution to hypertension and dyslipidemia in normal-weight Japanese individuals. DESIGN: Cross-sectional study. SUBJECTS: Apparently healthy Japanese subjects with a body mass index (BMI) between 20 and 23.5 kg/m 2 (265 males and 741 females, age 21-69 y). MEASUREMENTS: BMI, waist circumference (WC), waist-hip ratio (WHR), systolic and diastolic blood pressure, serum levels of total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C) and triglyceride (TG) were measured. Low-density lipoprotein-cholesterol (LDL-C) was calculated by the Friedewald formula. Percentage fat mass (%FM) and trunk fat mass-leg fat mass ratio (FM trunk /FM legs ) were obtained by dual-energy X-ray absorptiometry. RESULTS: WC, WHR, %FM and FM trunk /FM legs were significantly correlated with TC, LDL-C, HDL-C and TG with the tendency of FM trunk /FM legs to show the strongest correlations. For %FM and FM trunk /FM legs in both sexes, odds ratios (ORs) of the third tertiles with respect to the first tertiles increased for LDL-C elevation, TG elevation and dyslipidemia. In males, ORs of the third fertiles of WC were significantly high for LDL-C elevation and dyslipidemia whereas those of WHR were high for TG elevation and dyslipidemia. ORs of the third tertiles of WC and WHR were significantly high for TG elevation in females. BMI was not associated with the risk of abnormal lipid levels. ORs for hypertension showed significant increases in none of the variables of obesity. CONCLUSIONS: Excess accumulation of FM, especially to the upper body, was related to dyslipidemia in normal-weight subjects. Simple anthropometric variables, WC and WHR, may be useful for screening and management of dyslipidemia in these subjects.

Original languageEnglish
Pages (from-to)242-247
Number of pages6
JournalInternational Journal of Obesity
Volume28
Issue number2
DOIs
Publication statusPublished - Jan 1 2004

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Dyslipidemias
Adipose Tissue
Fats
Weights and Measures
Waist-Hip Ratio
Waist Circumference
Leg
LDL Cholesterol
Odds Ratio
HDL Cholesterol
Triglycerides
Body Mass Index
Cholesterol
Blood Pressure
Hypertension
Sex Ratio
Photon Absorptiometry
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Excess accumulation of body fat is related to dyslipidemia in normal-weight subjects. / Ito, H.; Nakasuga, K.; Ohshima, A.; Sakai, Y.; Maruyama, Toru; Kaji, Y.; Harada, M.; Jingu, S.; Sakamoto, M.

In: International Journal of Obesity, Vol. 28, No. 2, 01.01.2004, p. 242-247.

Research output: Contribution to journalArticle

Ito, H, Nakasuga, K, Ohshima, A, Sakai, Y, Maruyama, T, Kaji, Y, Harada, M, Jingu, S & Sakamoto, M 2004, 'Excess accumulation of body fat is related to dyslipidemia in normal-weight subjects', International Journal of Obesity, vol. 28, no. 2, pp. 242-247. https://doi.org/10.1038/sj.ijo.0802528
Ito, H. ; Nakasuga, K. ; Ohshima, A. ; Sakai, Y. ; Maruyama, Toru ; Kaji, Y. ; Harada, M. ; Jingu, S. ; Sakamoto, M. / Excess accumulation of body fat is related to dyslipidemia in normal-weight subjects. In: International Journal of Obesity. 2004 ; Vol. 28, No. 2. pp. 242-247.
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T1 - Excess accumulation of body fat is related to dyslipidemia in normal-weight subjects

AU - Ito, H.

AU - Nakasuga, K.

AU - Ohshima, A.

AU - Sakai, Y.

AU - Maruyama, Toru

AU - Kaji, Y.

AU - Harada, M.

AU - Jingu, S.

AU - Sakamoto, M.

PY - 2004/1/1

Y1 - 2004/1/1

N2 - OBJECTIVE: To assess the relationship of fat mass (FM) and its distribution to hypertension and dyslipidemia in normal-weight Japanese individuals. DESIGN: Cross-sectional study. SUBJECTS: Apparently healthy Japanese subjects with a body mass index (BMI) between 20 and 23.5 kg/m 2 (265 males and 741 females, age 21-69 y). MEASUREMENTS: BMI, waist circumference (WC), waist-hip ratio (WHR), systolic and diastolic blood pressure, serum levels of total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C) and triglyceride (TG) were measured. Low-density lipoprotein-cholesterol (LDL-C) was calculated by the Friedewald formula. Percentage fat mass (%FM) and trunk fat mass-leg fat mass ratio (FM trunk /FM legs ) were obtained by dual-energy X-ray absorptiometry. RESULTS: WC, WHR, %FM and FM trunk /FM legs were significantly correlated with TC, LDL-C, HDL-C and TG with the tendency of FM trunk /FM legs to show the strongest correlations. For %FM and FM trunk /FM legs in both sexes, odds ratios (ORs) of the third tertiles with respect to the first tertiles increased for LDL-C elevation, TG elevation and dyslipidemia. In males, ORs of the third fertiles of WC were significantly high for LDL-C elevation and dyslipidemia whereas those of WHR were high for TG elevation and dyslipidemia. ORs of the third tertiles of WC and WHR were significantly high for TG elevation in females. BMI was not associated with the risk of abnormal lipid levels. ORs for hypertension showed significant increases in none of the variables of obesity. CONCLUSIONS: Excess accumulation of FM, especially to the upper body, was related to dyslipidemia in normal-weight subjects. Simple anthropometric variables, WC and WHR, may be useful for screening and management of dyslipidemia in these subjects.

AB - OBJECTIVE: To assess the relationship of fat mass (FM) and its distribution to hypertension and dyslipidemia in normal-weight Japanese individuals. DESIGN: Cross-sectional study. SUBJECTS: Apparently healthy Japanese subjects with a body mass index (BMI) between 20 and 23.5 kg/m 2 (265 males and 741 females, age 21-69 y). MEASUREMENTS: BMI, waist circumference (WC), waist-hip ratio (WHR), systolic and diastolic blood pressure, serum levels of total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C) and triglyceride (TG) were measured. Low-density lipoprotein-cholesterol (LDL-C) was calculated by the Friedewald formula. Percentage fat mass (%FM) and trunk fat mass-leg fat mass ratio (FM trunk /FM legs ) were obtained by dual-energy X-ray absorptiometry. RESULTS: WC, WHR, %FM and FM trunk /FM legs were significantly correlated with TC, LDL-C, HDL-C and TG with the tendency of FM trunk /FM legs to show the strongest correlations. For %FM and FM trunk /FM legs in both sexes, odds ratios (ORs) of the third tertiles with respect to the first tertiles increased for LDL-C elevation, TG elevation and dyslipidemia. In males, ORs of the third fertiles of WC were significantly high for LDL-C elevation and dyslipidemia whereas those of WHR were high for TG elevation and dyslipidemia. ORs of the third tertiles of WC and WHR were significantly high for TG elevation in females. BMI was not associated with the risk of abnormal lipid levels. ORs for hypertension showed significant increases in none of the variables of obesity. CONCLUSIONS: Excess accumulation of FM, especially to the upper body, was related to dyslipidemia in normal-weight subjects. Simple anthropometric variables, WC and WHR, may be useful for screening and management of dyslipidemia in these subjects.

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