Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats

Takuya Kishi, K. Sunagawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

23 Citations (Scopus)

Abstract

One of the important organ damage of hypertension is cognitive decline. Cognitive function is determined by the function of hippocampus, and previous studies have suggested that the decrease in brain-derived neurotrophic factor (BDNF) in the hippocampus causes cognitive decline. Protection against cognitive decline is reported not only in pharmacological therapy but also in exercise training or calorie restriction. The aim of the present study was to determine whether exercise training plus calorie restriction cause synergistic protection against cognitive decline via BDNF in the hippocampus or not. Exercise training for 28 days improved cognitive decline determined by Morris water maze test via up-regulation of BDNF in the hippocampus of stroke-prone spontaneously hypertensive rats, whereas calorie restriction for 28 days did not. However, exercise training plus calorie restriction causes the protection against cognitive decline to a greater extent than exercise training alone. In conclusion, exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in the hippocampus of stroke-prone hypertensive rats.

Original languageEnglish
Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
Pages6764-6767
Number of pages4
DOIs
Publication statusPublished - Dec 14 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: Aug 28 2012Sep 1 2012

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
CountryUnited States
CitySan Diego, CA
Period8/28/129/1/12

Fingerprint

Brain-Derived Neurotrophic Factor
Rats
Hippocampus
Brain
Up-Regulation
Stroke
Exercise
Inbred SHR Rats
Cognitive Dysfunction
Nerve Growth Factors
Cognition
Water
Pharmacology
Hypertension

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Kishi, T., & Sunagawa, K. (2012). Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats. In 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012 (pp. 6764-6767). [6347547] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2012.6347547

Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats. / Kishi, Takuya; Sunagawa, K.

2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012. 2012. p. 6764-6767 6347547 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kishi, T & Sunagawa, K 2012, Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats. in 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012., 6347547, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 6764-6767, 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012, San Diego, CA, United States, 8/28/12. https://doi.org/10.1109/EMBC.2012.6347547
Kishi T, Sunagawa K. Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats. In 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012. 2012. p. 6764-6767. 6347547. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2012.6347547
Kishi, Takuya ; Sunagawa, K. / Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012. 2012. pp. 6764-6767 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
@inproceedings{db6f58aca7a04a15adc9a6c42fbbf932,
title = "Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats",
abstract = "One of the important organ damage of hypertension is cognitive decline. Cognitive function is determined by the function of hippocampus, and previous studies have suggested that the decrease in brain-derived neurotrophic factor (BDNF) in the hippocampus causes cognitive decline. Protection against cognitive decline is reported not only in pharmacological therapy but also in exercise training or calorie restriction. The aim of the present study was to determine whether exercise training plus calorie restriction cause synergistic protection against cognitive decline via BDNF in the hippocampus or not. Exercise training for 28 days improved cognitive decline determined by Morris water maze test via up-regulation of BDNF in the hippocampus of stroke-prone spontaneously hypertensive rats, whereas calorie restriction for 28 days did not. However, exercise training plus calorie restriction causes the protection against cognitive decline to a greater extent than exercise training alone. In conclusion, exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in the hippocampus of stroke-prone hypertensive rats.",
author = "Takuya Kishi and K. Sunagawa",
year = "2012",
month = "12",
day = "14",
doi = "10.1109/EMBC.2012.6347547",
language = "English",
isbn = "9781424441198",
series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",
pages = "6764--6767",
booktitle = "2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012",

}

TY - GEN

T1 - Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats

AU - Kishi, Takuya

AU - Sunagawa, K.

PY - 2012/12/14

Y1 - 2012/12/14

N2 - One of the important organ damage of hypertension is cognitive decline. Cognitive function is determined by the function of hippocampus, and previous studies have suggested that the decrease in brain-derived neurotrophic factor (BDNF) in the hippocampus causes cognitive decline. Protection against cognitive decline is reported not only in pharmacological therapy but also in exercise training or calorie restriction. The aim of the present study was to determine whether exercise training plus calorie restriction cause synergistic protection against cognitive decline via BDNF in the hippocampus or not. Exercise training for 28 days improved cognitive decline determined by Morris water maze test via up-regulation of BDNF in the hippocampus of stroke-prone spontaneously hypertensive rats, whereas calorie restriction for 28 days did not. However, exercise training plus calorie restriction causes the protection against cognitive decline to a greater extent than exercise training alone. In conclusion, exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in the hippocampus of stroke-prone hypertensive rats.

AB - One of the important organ damage of hypertension is cognitive decline. Cognitive function is determined by the function of hippocampus, and previous studies have suggested that the decrease in brain-derived neurotrophic factor (BDNF) in the hippocampus causes cognitive decline. Protection against cognitive decline is reported not only in pharmacological therapy but also in exercise training or calorie restriction. The aim of the present study was to determine whether exercise training plus calorie restriction cause synergistic protection against cognitive decline via BDNF in the hippocampus or not. Exercise training for 28 days improved cognitive decline determined by Morris water maze test via up-regulation of BDNF in the hippocampus of stroke-prone spontaneously hypertensive rats, whereas calorie restriction for 28 days did not. However, exercise training plus calorie restriction causes the protection against cognitive decline to a greater extent than exercise training alone. In conclusion, exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in the hippocampus of stroke-prone hypertensive rats.

UR - http://www.scopus.com/inward/record.url?scp=84884177468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884177468&partnerID=8YFLogxK

U2 - 10.1109/EMBC.2012.6347547

DO - 10.1109/EMBC.2012.6347547

M3 - Conference contribution

C2 - 23367482

AN - SCOPUS:84884177468

SN - 9781424441198

T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

SP - 6764

EP - 6767

BT - 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012

ER -