Exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in hippocampus of stroke-prone hypertensive rats

T. Kishi, K. Sunagawa

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    26 Citations (Scopus)

    Abstract

    One of the important organ damage of hypertension is cognitive decline. Cognitive function is determined by the function of hippocampus, and previous studies have suggested that the decrease in brain-derived neurotrophic factor (BDNF) in the hippocampus causes cognitive decline. Protection against cognitive decline is reported not only in pharmacological therapy but also in exercise training or calorie restriction. The aim of the present study was to determine whether exercise training plus calorie restriction cause synergistic protection against cognitive decline via BDNF in the hippocampus or not. Exercise training for 28 days improved cognitive decline determined by Morris water maze test via up-regulation of BDNF in the hippocampus of stroke-prone spontaneously hypertensive rats, whereas calorie restriction for 28 days did not. However, exercise training plus calorie restriction causes the protection against cognitive decline to a greater extent than exercise training alone. In conclusion, exercise training plus calorie restriction causes synergistic protection against cognitive decline via up-regulation of BDNF in the hippocampus of stroke-prone hypertensive rats.

    Original languageEnglish
    Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
    Pages6764-6767
    Number of pages4
    DOIs
    Publication statusPublished - 2012
    Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
    Duration: Aug 28 2012Sep 1 2012

    Publication series

    NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
    ISSN (Print)1557-170X

    Other

    Other34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
    CountryUnited States
    CitySan Diego, CA
    Period8/28/129/1/12

    All Science Journal Classification (ASJC) codes

    • Signal Processing
    • Biomedical Engineering
    • Computer Vision and Pattern Recognition
    • Health Informatics

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