Existence of suppressor cells in the spleen of allogeneic and syngeneic primiparous pregnant mice

Masatoshi Sano, Shunji Miake, Yasunobu Yoshikai, Kikuo Nomoto

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    Mixed lymphocyte reaction (MLR) and in vitro induction of cytolytic cells against alloantigens were investigated using spleen cells from primiparous mice mated allogeneically or syngeneically. One-way MLR was reduced significantly in degree not only in allogeneic but also in syngeneic pregnant mice. MLR of virgin spleen cells was suppressed when mitomycin C-treated spleen cells taken from syngeneic or allogeneic pregnant mice were added as regulator cells. These suppressive effects disappeared when regulator cells were treated with anti-Thy 1 or anti-Lyt 2 serum plus complement. Generation of cytotoxic lymphocytes from syngeneic or allogeneic pregnancy spleen cells in MLR was depressed compared with that from virgin spleen cells. The addition of pregnancy spleen cells to MLR suppressed in vitro generation of cytotoxic lymphocytes from virgin spleen cells. These results indicated that reduction of in vitro cellular responses of pregnancy spleen cells was due to suppressor cells in the spleens. These cells suppressed non-specifically the reactions to alloantigens and could be detected both in allogeneic and syngeneic primiparous pregnancies.

    Original languageEnglish
    Pages (from-to)239-251
    Number of pages13
    JournalJournal of Reproductive Immunology
    Volume6
    Issue number4
    DOIs
    Publication statusPublished - Jan 1 1984

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology
    • Reproductive Medicine
    • Obstetrics and Gynaecology

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